We consider the Dirichlet Laplacian H γ on a 3D twisted waveguide with random Anderson-type twisting γ. We introduce the integrated density of states N γ for the operator H γ , and investigate the Lifshits tails of N γ , i.e. the asymptotic behavior of N γ (E) as E ↓ inf supp dN γ . In particular, we study the dependence of the Lifshits exponent on the decay rate of the single-site twisting at infinity.