LIFU-responsive nanomedicine enables acoustic droplet vaporization-induced apoptosis of macrophages for stabilizing vulnerable atherosclerotic plaques

Visualization system based on hierarchical targeting for diagnosis and treatment of hepatocellular carcinoma

“…The controlled release of the drug is significant for its therapeutic efficacy and biosafety, and the controlled phase changeability of PFP under LIFU irradiation has also been verified in a large number of experiments [ 40 , 43 ]. The phase changeability of the nanoparticles showed significant energy dependence under the same LIFU irradiation time ( Fig.…”

“…Nanoscale liposomes enhance the ultrasound (US) imaging capability when transformed to micron-scale or even larger sizes [ 40 ]. We used the parameters of the LIFU release drug experiment for the experiment of US imaging capability, and the MNDs/mMNDs after different treatments were observed using ultrasound diagnostic system (Mylab 90, Esaote, Italy); the image grayscale was analyzed using DFY software (Chongqing Medical University, China).…”

Thrombus-targeted nano-agents for NIR-II diagnostic fluorescence imaging-guided flap thromboembolism multi-model therapy

“…High-intensity ultrasound was also introduced to treat thrombus. However, ultrasound would break the thrombus instead of ablation for mild therapy [20][21][22]. Besides ultrasound, photothermal therapy (PTT) [23,24] and photodynamic cure (PDT) [25] have been found to have an efficient therapeutic effect for thrombolytic treatment.…”

Thrombus-targeted Nano-agents for NIR-II Diagnostic Fluorescence Imaging-guided Flap Thromboembolism Multi-model Therapy

“…For instance, assorted targeted delivery strategies have been explored, but they did not alter the nature of drug thrombolysis and the risk of drug leakage still exists. High-intensity ultrasound has been introduced to treat thrombus, of which in nature ultrasound would break the thrombus instead of ablation for mild therapy [18,27,28] . Besides ultrasound, photothermal therapy (PTT) [29,30] and photodynamic therapy (PDT) [31] have been found to have an e cient therapeutic effect for thrombolytic treatment.…”