Ligand concentration determines antiviral efficacy of silica multivalent nanoparticles

Wang, Heyun; Xu, Xufeng; Polla, Rémi La; Silva, Paulo Jacob; Ong, Quy Khac; Stellacci, Francesco

doi:10.1016/j.jcis.2023.11.122

Cited by 3 publications

(1 citation statement)

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“…Richter et al [ 151 ] presented gold nanoparticles with different ratios of negatively charged (11-mercapto 1-undecanesulfonic acid) and hydrophobic (1-octanethiol) ligands that can cause deactivation through electrostatic attaching to the surface of the virion. Very recently, it was shown that the concentration of ligands at the surface of nanoparticles plays a crucial role in the process [ 152 ].…”

Section: Future Outlook: New Antiphagentsmentioning

confidence: 99%

Bacteriophage Challenges in Industrial Processes: A Historical Unveiling and Future Outlook

Kamiński,

Paczesny

2024

Pathogens

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Humans have used fermentation processes since the Neolithic period, mainly to produce beverages. The turning point occurred in the 1850s, when Louis Pasteur discovered that fermentation resulted from the metabolism of living microorganisms. This discovery led to the fast development of fermented food production. The importance of industrial processes based on fermentation significantly increased. Many branches of industry rely on the metabolisms of bacteria, for example, the dairy industry (cheese, milk, yogurts), pharmaceutical processes (insulin, vaccines, antibiotics), or the production of chemicals (acetone, butanol, acetic acid). These are the mass production processes involving a large financial outlay. That is why it is essential to minimize threats to production. One major threat affecting bacteria-based processes is bacteriophage infections, causing substantial economic losses. The first reported phage infections appeared in the 1930s, and companies still struggle to fight against phages. This review shows the cases of phage infections in industry and the most common methods used to prevent phage infections.

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Section: Future Outlook: New Antiphagentsmentioning

confidence: 99%