Ligand-free copper-catalyzed denitrogenative arylation of phosphorylamides with arylhydrazines

Nickel-catalyzed reductive coupling of nitroarenes and phosphine oxides to access phosphinic amides

“…One approach is the arylation of primary phosphinamide through transition metal-catalyzed cross-coupling reactions. 2 However, the preparation of primary phosphinamide is necessary in this case (Scheme 1b). Another method involves the oxidative coupling of phosphine oxides with amines, which has been developed by Tan, Chen, Guo, Lu, and Gu research groups (Scheme 1c).…”

Enantioselective hydrogen-bond-donor catalysis to access diverse stereogenic-at-P(V) compounds

“…High enantioselectivity was obtained using N -allyl benzylamine in the substitution reaction under modified conditions. The benzyl group and the allyl group on the chlorophosphonamidate products can each be cleaved successively, enabling their sequential replacement (see supplementary materials) ( 44 – 48 ). This strategy was exploited in the synthesis of phosphonamidate 17 , a matrix metalloproteinase (MMP) inhibitor with demonstrated anticancer activity (Fig.…”