Ligand recognition and signal transduction by lectin receptor-like kinases in plant immunity

Lu, Lu; Liu, Jun; Xu, Ning

doi:10.3389/fpls.2023.1201805

Cited by 3 publications

(2 citation statements)

References 142 publications

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“…Our findings highlight the importance of the putative IDR in the extended C terminus of P2K1 in regulating eATP signaling, especially in the eATP-induced regulation of primary root growth. Additionally, our results suggest a critical role for eATP and P2K1 in regulating ROS and cell wall integrity in the primary root meristem, which are essential for plant growth and stress adaptation [57][58][59][60][61][62][63]. This study also provides a framework for generating other truncated RK variants based on IDRs that can help further unravel the functional significance of the C terminus in other receptor proteins.…”

Section: Discussionmentioning

confidence: 98%

The intrinsically disordered C‐terminus of purinoceptor P2K1 fine‐tunes plant responses to extracellular ATP

et al. 2023

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P2K1 is a plant‐specific purinoceptor that perceives extracellular ATP (eATP), a signaling molecular implicated in various physiological processes. Interestingly, P2K1 harbors a C‐terminal intrinsically disordered region (IDR). When we overexpressed a truncated P2K1 (P2K1t) lacking the IDR, primary root growth completely ceased in response to eATP. We investigated the functional roles of the IDR in P2K1 using a combination of molecular genetics, calcium imaging, gene expression analysis, and histochemical approaches. We found that the P2K1t variant gave rise to an amplified response to eATP, through accumulation of superoxide, altered cell wall integrity, and ultimate cell death in the primary root tip. Together, these observations underscore the significant involvement of the C‐terminal tail of P2K1 in root growth regulation.

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Section: Discussionmentioning

confidence: 98%

The intrinsically disordered C‐terminus of purinoceptor P2K1 fine‐tunes plant responses to extracellular ATP

et al. 2023

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“…Our study showed that MuLRR-RLK protein structure has a high homology to other LRR-RLK proteins ( Figure 5 ), indicating that it might have similar biological functions as other LRR-RLK proteins in the same subfamilies. It was reported that LRR-RLKs play vital roles in plant growth, development, and the responses to environmental stress, and some LRR-RLKs are associated with plant resistance to bacterial and fungal pathogen invasion [ 63 , 64 , 65 ]. However, to our knowledge, this is the first report that LRR-RLK genes are associated with the response to phytoplasma infection.…”

Section: Discussionmentioning

confidence: 99%

Integrated Analysis of lncRNAs and mRNAs Reveals Complex Gene Network Mediated by lncRNAs and Regulatory Function of MuLRR-RLK-AS in Response to Phytoplasma Infection in Mulberry

Liu,

Zhao

et al. 2024

Biomolecules

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Phytoplasma disease is one of the most serious infectious diseases that affects the growth and development of mulberry. Long non-coding RNAs (lncRNAs) play an important role in plants’ defense systems; however, the contribution of lncRNAs in the response to phytoplasma infection in mulberry is still largely unknown. Herein, strand-specific RNA sequencing was performed to profile the mRNAs and lncRNAs involved in the response to phytoplasma infection in mulberry, and a total of 4169 genes were found to be differentially expressed (DE) between healthy and phytoplasma-infected leaves. Moreover, 1794 lncRNAs were identified, of which 742 lncRNAs were DE between healthy and infected leaves. Target prediction showed that there were 68 and 44 DE lncRNAs which may function as cis and trans-regulators, targeting 54 and 44 DE genes, respectively. These DE target genes are associated with biological processes such as metabolism, signaling, development, transcriptional regulation, etc. In addition, it was found that the expression of the antisense lncRNA (MuLRR-RLK-AS) of the leucine-rich repeat receptor-like protein kinase gene (MuLRR-RLK) was decreased in the phytoplasma-infected leaves. Interestingly, it was found that overexpression of MuLRR-RLK-AS can inhibit the expression of MuLRR-RLK. Moreover, it was found that the expression levels of PTI-related and MAPK genes in the transgenic MuLRR-RLK Arabidopsis plants were significantly higher than those in the wild-type plants when inoculated with pathogens, and the transgenic plants were conferred with strong disease resistance. Our results demonstrate that MuLRR-RLK-AS, as a trans-regulatory factor, can inhibit the expression of the MuLRR-RLK gene and is a negative regulatory factor for mulberry resistance. The information provided is particularly useful for understanding the functions and mechanisms of lncRNAs in the response to phytoplasma infection in mulberry.

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Genome-Wide Identification of the Lectin Receptor-like Kinase Gene Family in Avena sativa and Its Role in Salt Stress Tolerance

Xiong,

Cui,

Tian

et al. 2024

IJMS

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Lectin receptor-like kinases (LecRLKs) are membrane-bound receptor genes found in many plant species. They are involved in perceiving stresses and responding to the environment. Oat (Avena sativa; 2n = 6x = 42) are an important food and forage crop with potential in drought, saline, or alkaline soils. Here, we present a comprehensive genome-wide analysis of the LecRLK gene family in A. sativa and the crop’s wild relatives A. insularis (4x) and A. longiglumis (2x), unveiling a rich diversity with a total of 390 LecRLK genes identified, comprising 219 G-types, 168 L-types, and 3 C-types in oats. Genes were unevenly distributed across the oat chromosomes. GFP constructs show that family members were predominantly located in the plasma membrane. Expression under salt stress demonstrated functional redundancy and differential expression of LecRLK gene family members in oats: 173 members of this family were involved in the response to salt stress, and the expression levels of three C-type genes in the root and leaf were significantly increased under salt stress. The results show the diversity, evolutionary dynamics, and functional implications of the LecRLK gene family in A. sativa, setting a foundation for defining its roles in plant development and stress resilience, and suggesting its potential agricultural application for crop improvement.

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Ligand recognition and signal transduction by lectin receptor-like kinases in plant immunity

Cited by 3 publications

References 142 publications

The intrinsically disordered C‐terminus of purinoceptor P2K1 fine‐tunes plant responses to extracellular ATP

The intrinsically disordered C‐terminus of purinoceptor P2K1 fine‐tunes plant responses to extracellular ATP

Integrated Analysis of lncRNAs and mRNAs Reveals Complex Gene Network Mediated by lncRNAs and Regulatory Function of MuLRR-RLK-AS in Response to Phytoplasma Infection in Mulberry

Genome-Wide Identification of the Lectin Receptor-like Kinase Gene Family in Avena sativa and Its Role in Salt Stress Tolerance

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