2001
DOI: 10.1002/1521-3757(20010903)113:17<3194::aid-ange3194>3.0.co;2-7
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Ligandengesteuerte Ionenkanäle

Abstract: Ionenkanäle spielen eine zentrale Rolle bei zahlreichen biologischen Prozessen wie der Nervenaktivität oder der Muskelkontraktion. Wie kommt es zu ihrer beeindruckenden Ionenselektivität, wie zur Steuerung der Kanalöffnung durch spezifische Signale? In den letzten Jahren haben Röntgenkristallographie, hochauflösende Elektronenmikroskopie und der Einsatz weiterer Methoden wie der Photoaffinitäts‐Markierung und der ortsspezifischen Mutagenese in Verbindung mit Patch‐Clamp‐Elektrophysiologie ein detailreiches Bil… Show more

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Cited by 10 publications
(11 citation statements)
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References 118 publications
(111 reference statements)
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“…These receptor proteins share a high degree of homology at both the protein and nucleic acid level, a fact indicating that ligand-gated ion channels originate from common ancestral genes. [2,6,7] Numerous biochemical data, [8,9] hydropathy assignments and structural data from electron microscopy [10±12] and NMR spectroscopy [13±17] have led to the current four-transmembrane-helix model for ion channels that are nicotinic acetylcholine receptor like (Figure 2 D). [2,8,9] While ionotropic glutamate receptors also belong among the group of directly ligand gated ion channels, they are structurally more closely related to the voltage-gated receptor family.…”
Section: Introductionmentioning
confidence: 99%
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“…These receptor proteins share a high degree of homology at both the protein and nucleic acid level, a fact indicating that ligand-gated ion channels originate from common ancestral genes. [2,6,7] Numerous biochemical data, [8,9] hydropathy assignments and structural data from electron microscopy [10±12] and NMR spectroscopy [13±17] have led to the current four-transmembrane-helix model for ion channels that are nicotinic acetylcholine receptor like (Figure 2 D). [2,8,9] While ionotropic glutamate receptors also belong among the group of directly ligand gated ion channels, they are structurally more closely related to the voltage-gated receptor family.…”
Section: Introductionmentioning
confidence: 99%
“…[1] The excitatory neurotransmitters acetylcholine, glutamate and serotonin open cation channels (Na , Ca 2 ) which depolarise the postsynaptic cell, thus facilitating the generation of an action potential. [2] Inhibitory neurotransmitters, such as glycine and g-aminobutyric acid (GABA), activate anion channels (Cl À , HCO 3 À ) that lead to hyperpolarisation, thereby suppressing neuronal firing. When the inhibitory function of glycine receptors is considered, it should be remembered that the expression of chloride transporters, and thus the chloride potential in neurons, is developmentally regulated.…”
Section: Introductionmentioning
confidence: 99%
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