Ligational and analytical applications of a uracil derivative toward some transition metal ions

Synthesis, characterization and anticancer activity of 3-aminopyrazine-2-carboxylic acid transition metal complexes

“…The hematological parameters including haemoglobin (Hb), red blood cells count (RBCs) and white blood cells count (WBCs) data are reported in Table 2. It is clear that the hematological MSt/day e (12-16 g/dL) (4.0-6.0 9 10 6 cell/cm 3 ) (35.0-50.0%) (4,000-11,000 9 10 6 cell/cm 3 ) (910 6 (1), (11) and (14) exhibit much better figures with the use of small doses (0.01 mg/mice/day) compared with the standard market drug 5-fu (*0.4 mg/mice/day).There are reports that, complexes containing the pyridine ring display significant anticancer activity [7,36]. Thus, the presence of the coordinated pyrazine ring might increase the anticancer activity as it contains two cyclic nitrogen atoms [30].…”

“…The absence of any peak around 1700 cm -1 suggests that the carboxylate group is involved in the coordination [21]. The bands at 3329 and 3468 cm -1 in Hapc assigned to m s (NH 2 ) and m as (NH 2 ) stretches, respectively, are shifted to lower wavenumber in the complexes due to coordination of the amino nitrogen atom to the metal atom [7,23]. The strong band near 1606 cm -1 assigned to d(NH 2 ) in Hapc is shifted to ca.…”

“…We have previously reported the chemistry and anticancer activity of some transition metal complexes of 4,6-diamino-5-hydroxy-2-mercaptopyrimidine [4][5][6] and 5,6-diamino-2,4-dihydroxypyrimidine [7]. Pyrazines and its derivatives form an important class of compounds present in many natural flavours and complicated organic molecules [8].…”

Biologically active 2-thione-4,6-diamino-5-hydroxypyrimidine transition metal complexes

“…The bands arising from m(C=N), m(NCS) and m(C=S) are not affected while the bands arising from both the m(NH) and d(NH) stretches are shifted slightly to lower wave number in the complexes. This indicates that HTDAHP acts as a bidentate ligand, chelating the metal ion through the deprotonated hydroxy and amino N(6)H 2 groups, without any participation of the thione sulphur or cyclic nitrogen atoms in coordination [16]. This feature is further supported by the observation of a band near 1178 cm -1 arising from the m(C=S) stretch, which remains unchanged [20].…”

“…We have reported the interaction of 5,6-diamino-2,4-dihydroxypyrimidine hemisulfate with some transition metal ions [16]. The complexes obtained from the reaction of 2-thione-4,6-diamino-5-hydroxypyrimidine (HTDAHP) with Fe(III), Ni(II), Ru(II) and Ag(I) are described in this article.…”