Light-activated nanoclusters with tunable ROS for wound infection treatment

Wang, Xin; Ding, Jianing; Chen, Xiao; Wang, Sicheng; Chen, Zhiheng; Chen, Yuanyuan; Zhang, Guowang; Liu, Ji; Shi, Tingwang; Song, Jian; Sheng, Shihao; Wang, Guangchao; Xu, Jianguang; Su, Jiacan; Zhang, Wei; Lian, Xiaofeng

doi:10.1016/j.bioactmat.2024.07.009

Bioactive Materials

2024

DOI: 10.1016/j.bioactmat.2024.07.009

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Light-activated nanoclusters with tunable ROS for wound infection treatment

Xin Wang,

Jianing Ding,

Xiao Chen

et al.

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Cited by 2 publications

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Multifunctional SEBS/AgNWs Nanocomposite Films with Antimicrobial, Antioxidant, and Anti-Inflammatory Properties Promote Infected Wound Healing

Chen,

Amona,

Chen

et al. 2024

ACS Appl. Mater. Interfaces

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Wound healing is a complex biological process that can trigger inflammation and oxidative stress and impair myofibrillogenesis and angiogenesis. Several advanced wounddressing nanocomposite materials have been designed to address these issues. Here, we designed a new multifunctional styrene−ethylene−butylene−styrene/silver nanowire (SEBS/ AgNWs)-based nanocomposite film with antimicrobial, antioxidant, and anti-inflammatory properties to promote wound healing. The porous morphological structure of SEBS/AgNWs enhances their antimicrobial, antioxidant, and anti-inflammatory properties. SEBS/AgNWs significantly inhibited the growth of Staphylococcus aureus, methicillin-resistant Staphylococcus aureus, and Escherichia coli strains, effectively wiping out ABTS•+, DPPH•, hydrogen peroxide (H 2 O 2 ), and hydroxyl (•OH) radicals, showing their effective ROS-scavenging properties. It further showed significant antioxidant properties by increasing the levels of enzyme-like catalase (CAT), superoxide dismutase (SOD), and glutathione (GSH), while decreasing malonaldehyde (MDA) levels. Additionally, SEBS/AgNWs reduced the expression of interleukin-1β (IL-1β), IL-6, and tumor necrosis factor-α (TNF-α), while increasing levels of transforming growth factor-β (TGF-β), vascular endothelial growth factor-A (VEGF), and CD31 in wound healing. This suggests that applying a multifunctional nanoplatform based on SEBS/AgNWs could enhance wound healing and improve patient outcomes in wound care management.

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Multifunctional SEBS/AgNWs Nanocomposite Films with Antimicrobial, Antioxidant, and Anti-Inflammatory Properties Promote Infected Wound Healing

Chen,

Amona,

Chen

et al. 2024

ACS Appl. Mater. Interfaces

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Multifunctional Ti₃C₂@PDA/CuO₂ Nanoplatform for Synergistic Photothermal, Photodynamic and Photothermal-Enhanced Chemodynamic Antibacterial Therapy

Ge,

Yuan,

Wang

et al. 2024

ACS Appl. Nano Mater.

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The escalating threat of antibiotic resistance has necessitated the development of innovative antibacterial strategies. In this study, a nanoplatform, Ti 3 C 2 @PDA/CuO 2 , was engineered to exploit the synergistic effects of photothermal therapy (PTT), photodynamic therapy (PDT) and chemodynamic therapy (CDT) under near-infrared (NIR) light irradiation for the effective treatment of bacterial infections. Upon exposure to an 808 nm NIR laser and the application of hydrogen peroxide, the Ti 3 C 2 @PDA/CuO 2 nanoplatform demonstrated robust PTT, PDT and significantly photothermal-enhanced CDT activities. This multimodal therapeutic approach resulted in a pronounced antimicrobial response, as evidenced by in vitro assays that showed an extraordinary reduction in the viability of Escherichia coli and Staphylococcus aureus, with efficacies of 98.5% and 99.5%, respectively. Our findings contribute significant insights into the design of synergistic antibacterial strategies and offer a promising avenue for the development of advanced antimicrobial interventions.

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Light-activated nanoclusters with tunable ROS for wound infection treatment

Cited by 2 publications

References 58 publications

Multifunctional SEBS/AgNWs Nanocomposite Films with Antimicrobial, Antioxidant, and Anti-Inflammatory Properties Promote Infected Wound Healing

Multifunctional SEBS/AgNWs Nanocomposite Films with Antimicrobial, Antioxidant, and Anti-Inflammatory Properties Promote Infected Wound Healing

Multifunctional Ti₃C₂@PDA/CuO₂ Nanoplatform for Synergistic Photothermal, Photodynamic and Photothermal-Enhanced Chemodynamic Antibacterial Therapy

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Light-activated nanoclusters with tunable ROS for wound infection treatment

Cited by 2 publications

References 58 publications

Multifunctional SEBS/AgNWs Nanocomposite Films with Antimicrobial, Antioxidant, and Anti-Inflammatory Properties Promote Infected Wound Healing

Multifunctional SEBS/AgNWs Nanocomposite Films with Antimicrobial, Antioxidant, and Anti-Inflammatory Properties Promote Infected Wound Healing

Multifunctional Ti3C2@PDA/CuO2 Nanoplatform for Synergistic Photothermal, Photodynamic and Photothermal-Enhanced Chemodynamic Antibacterial Therapy

Contact Info

Product

Resources

About

Multifunctional Ti₃C₂@PDA/CuO₂ Nanoplatform for Synergistic Photothermal, Photodynamic and Photothermal-Enhanced Chemodynamic Antibacterial Therapy