Light‐Addressable Nanoclusters of Ultrasmall Iron Oxide Nanoparticles for Enhanced and Dynamic Magnetic Resonance Imaging of Arthritis

Li, Xin; Lu, Shiyi; Xiong, Zhi Hua; Hu, Yong; Ma, Dan; Lou, Wenqi; Peng, Chen; Shen, Mingwu; Shi, Xiangyang

doi:10.1002/advs.201901800

Cited by 80 publications

(74 citation statements)

References 45 publications

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“…Composite nanomaterials can make the targeted release of biological agents a reality, and the use of dipalmitoyl lecithin is an ideal method for nanoparticles to target AECs. 31 – 33 Exogenous siRNAs must pass through the cell membrane and reach a sufficient concentration in the cytoplasm to successfully silence the expression of specific genes. 34 However, a safe and effective transport vector has become an important obstacle in the development of this.…”

Section: Discussionmentioning

confidence: 99%

Tumor necrosis factor-α small interfering RNA alveolar epithelial cell-targeting nanoparticles reduce lung injury in C57BL/6J mice with sepsis

Qian

et al. 2021

J Int Med Res

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Background The role of tumor necrosis factor (TNF)-α small interfering (si)RNA alveolar epithelial cell (AEC)-targeting nanoparticles in lung injury is unclear. Methods Sixty C57BL/6J mice with sepsis were divided into normal, control, sham, 25 mg/kg, 50 mg/kg, and 100 mg/kg siRNA AEC-targeting nanoparticles groups (n = 10 per group). The wet:dry lung weight ratio, and hematoxylin and eosin staining, western blotting, and enzyme-linked immunosorbent assays for inflammatory factors were conducted to compare differences among groups. Results The wet:dry ratio was significantly lower in control and sham groups than other groups. TNF-α siRNA AEC-targeting nanoparticles significantly reduced the number of eosinophils, with significantly lower numbers in the 50 mg/kg group than in 25 mg/kg and 100 mg/kg groups. The nanoparticles also significantly reduced the expression of TNF-α, B-cell lymphoma-2, caspase 3, interleukin (IL)-1β, and IL-6, with TNF-α expression being significantly lower in the 50 mg/kg group than in 25 mg/kg and 100 mg/kg groups. Conclusion TNF-α siRNA AEC-targeting nanoparticles appear to be effective at improving lung injury-related sepsis, and 50 mg/kg may be a preferred dose option for administration.

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Section: Discussionmentioning

confidence: 99%

Tumor necrosis factor-α small interfering RNA alveolar epithelial cell-targeting nanoparticles reduce lung injury in C57BL/6J mice with sepsis

Qian

et al. 2021

J Int Med Res

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“…The ovarian carcinoma, especially, having the highest mortality rate in gynecological cancers, is difficult to theranostics drawing support from nanoplatforms due to its dense extracellular matrix [ 7 , 8 ]. In recent years, some novel nanocarriers have been designed by optimizing their physicochemical properties, such as size, softness, shape, surface charge and modification, to achieve highly efficient delivery, to improve theranostic efficacy and reduce systemic toxicity [ [9] , [10] , [11] , [12] , [13] ].…”

Section: Introductionmentioning

confidence: 99%

Dendrimer-decorated nanogels: Efficient nanocarriers for biodistribution in vivo and chemotherapy of ovarian carcinoma

Ouyang

et al. 2021

Bioactive Materials

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Nanomedicine has revolutionized disease theranostics by the accurate diagnosis and efficient therapy. Here, the PAMAM dendrimer decorated PVCL-GMA nanogels (NGs) were developed for favorable biodistribution in vivo and enhanced antitumor efficacy of ovarian carcinoma. By an ingenious design, the NGs with a unique structure that GMA-rich domains were localized on the surface were synthesized via precipitation polymerization. After G2 dendrimer decoration, the overall charge is changed from neutral to positive, and the NGs-G2 display the whole charge nature of positively charged corona and neutral core. Importantly, the unique architecture and charge conversion of NGs-G2 have a profound impact on the biodistribution and drug delivery in vivo . As a consequence of this alteration, the NGs-G2 as nanocarriers emerge the highly sought biodistribution of reduced liver accumulation, enhanced tumor uptake, and promoted drug release, resulting in the significantly augmented antitumor efficacy with low side effects. Remarkably, this finding is contrary to some reported work that the nanocarriers with positive charge have preferential liver uptake. Moreover, the NGs-G2 also displayed thermal/pH dual-responsive behaviors, excellent biocompatibility, improved cellular uptake, and stimuli-responsive drug release. Encouragingly, this work demonstrates a novel insight into the strategy for optimizing design, improving biodistribution and enhancing theranostic efficacy of nanocarriers.

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“…Targeted accumulation and multimode CT/PA/Thermal images of tumor For theranositc application in vivo, we established the subcutaneous xenograft of SKoV3 in nude mice as ovarian carcinoma model. The multimode images ability of theranostic nanoplatforms is critical for the accurate diagnosis, tumor localization, post-treatment and therapeutic outcome monitoring [49,50]. After intravenous injection (i.v.)…”

Section: Selective Anticancer Activity and Photothermal Ablation Of Omentioning

confidence: 99%

Safe and Efficient Molybdenum Disulfide Platform for Cooperative Imaging-Guided Photothermal-Selective Chemotherapy: A Preclinical Study

Kong

et al. 2021

Preprint

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Background The striking imbalance between the ever-increasing amount of nanomedicines and low clinical translation of products has become the focus of intense debate. For clinical translation, the critical issue is to select the appropriate agents and combination regimen for targeted diseases, not to prepare increasingly complex nanoplatforms. Methods Herein, a safe and efficient platform, α-tocopheryl succinate (α-TOS) married 2D molybdenum disulfide, was devised by a facile method and applied for cooperative imaging-guided photothermal-selective chemotherapy of ovarian carcinoma. Results The photothermal efficiency (65.3%) of the platform under safe near-infrared irradiation is much higher than that of other photothermal materials reported elsewhere. Moreover, the covalently linked α-TOS renders platform with selective chemotherapy for cancer cells. Remarkably, with these excellent properties, the platform can be used to completely eliminate the solid tumor by safe photothermal therapy, and then kill the residual cancer cells by selective chemotherapy to prevent tumor recurrence. More significantly, barely side effects occurred in the whole treatment process. The excellent efficacy and safety benefits in vivo lead to the prominent survival rate of 100% over 91 days. Conclusion Overall, the safe and efficient platform might be a candidate of clinical nanomedicines for multimode theranostics. This study demonstrates an innovative thought in precise nanomedicine regarding the design of next generation of cancer theranostic protocol for potential clinical practice.

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Light‐Addressable Nanoclusters of Ultrasmall Iron Oxide Nanoparticles for Enhanced and Dynamic Magnetic Resonance Imaging of Arthritis

Cited by 80 publications

References 45 publications

Tumor necrosis factor-α small interfering RNA alveolar epithelial cell-targeting nanoparticles reduce lung injury in C57BL/6J mice with sepsis

Tumor necrosis factor-α small interfering RNA alveolar epithelial cell-targeting nanoparticles reduce lung injury in C57BL/6J mice with sepsis

Dendrimer-decorated nanogels: Efficient nanocarriers for biodistribution in vivo and chemotherapy of ovarian carcinoma

Safe and Efficient Molybdenum Disulfide Platform for Cooperative Imaging-Guided Photothermal-Selective Chemotherapy: A Preclinical Study

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