1969
DOI: 10.1002/path.1710970221
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Light‐ and electron‐microscope studies on the granular cell myoblastoma of the tongue

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Cited by 114 publications
(37 citation statements)
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“…EVERSOLE et al [23] believed that the varied light and electron microscopic features of granular cell tumors could not possibly have substantiated a single specific progenitor cell in three cases and tney proposed tne term gran mai SIICUL11 iunkin iu' this tumor. Other investigators also believe that this lesion does not arise from a single cell type [21,22,24,25]. In our present case the relationship to nerve fibers and the existence of axon were not observed, but the tumor cells resembled Schwann cells in view of electron microscopic observations where the nuclei and cell membrane, …”
Section: Discussionsupporting
confidence: 41%
See 1 more Smart Citation
“…EVERSOLE et al [23] believed that the varied light and electron microscopic features of granular cell tumors could not possibly have substantiated a single specific progenitor cell in three cases and tney proposed tne term gran mai SIICUL11 iunkin iu' this tumor. Other investigators also believe that this lesion does not arise from a single cell type [21,22,24,25]. In our present case the relationship to nerve fibers and the existence of axon were not observed, but the tumor cells resembled Schwann cells in view of electron microscopic observations where the nuclei and cell membrane, …”
Section: Discussionsupporting
confidence: 41%
“…Most authors now believe that the tumor is not derived from a single cell type [21][22][23][24][25].…”
Section: Introductionmentioning
confidence: 99%
“…This theory has been challenged, however, by the presence of tumours in organs that lack striated muscle, 30 the absence of glycogen in tumour cells, and the absence of any similarity between tumour cells and striated muscle under electron microscopy (EM). 31 Researchers have subsequently proposed other cells of origin, including fibroblasts 32 and primitive mesenchymal cells, 10 as well as an origin resulting from metabolic derangement involving histiocytes. 33 The idea of GCT derivation from Schwann cells has gained popularity recently, mainly on the basis of evidence that the cytoplasmic granules in Schwann cells are indistinguishable from those found in GCT cells.…”
Section: Discussionmentioning
confidence: 99%
“…Histopathologically, it consists of S-100-protein-positive polygonal cells with abundant cytoplasm containing brightly acidophilic and PAS-positive and diastase-resistant granules [18]. …”
Section: Discussionmentioning
confidence: 99%