Light and electron microscopic study of the corneal stroma during the healing process of alkali-induced ulcer

Abstract

ResultsTwo weeks after alkali burn, corneal stromal neovascularization with the appearance of postcapillary venules was the most characteristic feature. This was associated with wide stromal spaces, inflammatory cellular infiltrate, activated fibroblasts, and irregularly deposited collagen. ConclusionDespite corneal reepithelialization, stromal changes might account for defective clarity following exposure to alkali.

Comparative Light and Electron Microscopic Study on the Therapeutic Efficacy of Adipose Derived Stem Cells Versus Exosomes for Experimentally Induced Acute Corneal Injuries in Rats

“…Our findings are also in agreement with other investigators [39] who mentioned that the wide intercellular spaces are due to disruption in desmosomes in epithelial cells of the deep layers. Meanwhile, disarrangement, destruction, and loss of collagen fibers are explained by apoptosis and loss of keratocytes responsible for collagen synthesis [3,14,40].…”