1975
DOI: 10.1093/infdis/131.6.678
|View full text |Cite
|
Sign up to set email alerts
|

Light and Electron Microscopic Study of Chlamydia trachomatis Infection of the Uterine Cervix

Abstract: Cervical biopsy specimens from two patients with infections caused by Chlamydia trachomatis (TRIC agent) were studied by means of light and electron microscopy. Intraepithelial vesicles containing C. trachomatis were present in the cervical mucosa. These intramucosal vesicles were readily recognized in paraffin sections by means of light microscopy. The developmental stages of C. trachomatis, which have previously been seen in tissue cell culture, chicken embryo, and conjunctival infections, were also apparent… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

2
25
0

Year Published

1979
1979
2015
2015

Publication Types

Select...
7
3

Relationship

0
10

Authors

Journals

citations
Cited by 51 publications
(27 citation statements)
references
References 20 publications
2
25
0
Order By: Relevance
“…The more extensive infection of bovine oviduct cultures, as indicated by the large number of C. psittaci organisms detected in the medium and tissue of the cultures, is in keeping with the ability to observe some histological and electron microscopical changes. These changes, in which all the elements of the chlamydial growth cycle were seen, were similar to those which have been observed in experimentally infected cell cultures (Manire, 1977) and in cervical epithelium naturally infected by C. trachomatis (Swanson et al, 1975). Infection of ciliated epithelial cells and shedding of infected cells from the epitheiial surface was evident.…”
Section: Discussionsupporting
confidence: 85%
“…The more extensive infection of bovine oviduct cultures, as indicated by the large number of C. psittaci organisms detected in the medium and tissue of the cultures, is in keeping with the ability to observe some histological and electron microscopical changes. These changes, in which all the elements of the chlamydial growth cycle were seen, were similar to those which have been observed in experimentally infected cell cultures (Manire, 1977) and in cervical epithelium naturally infected by C. trachomatis (Swanson et al, 1975). Infection of ciliated epithelial cells and shedding of infected cells from the epitheiial surface was evident.…”
Section: Discussionsupporting
confidence: 85%
“…1. The membrane structures of C. trachomatis are morphologically similar to free living Gram-negative bacteria with clearly defined inner and outer membrane systems (3,36,37,57), and C. trachomatis cells possess the gene set found in free-living bacteria like E. coli to generate the phospholipid components. Two differences are the absence of genes for unsaturated fatty acid synthesis and the use of an acyl-ACP-specific plant-like Gro-3-P acyltransferase.…”
Section: Discussionmentioning
confidence: 99%
“…Chlamydia1 genital infection in the adult female human involves the columnar epithelium lining mucosal surfaces of the uterus (Swanson et al, 1975;MQrdh et al, 1981) and fallopian tubes (Moller et ul., 1979) but not the squamous epithelium of the ectocervix (Evans, 1982;Mitao et al, 1984). C .…”
Section: Post-inoculationmentioning
confidence: 99%