Light and Life at Night as Circadian Rhythm Disruptors

Lee, Eunil; Kim, Mari

doi:10.33069/cim.2019.0016

Cited by 16 publications

(13 citation statements)

References 120 publications

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“…A growing number of epidemiological studies have reported evidence for an association between exposure to dLAN and several pathologies, including obesity (8), breast and prostate cancer (9), increased blood pressure (10), and sleep disorders (11). Because dLAN disturbs the natural light-dark (LD) cycles, circadian clocks are considered the primary system susceptible to improper functioning, underlying the link between dLAN and increased health risks (12,13). Indeed, after chronic exposure to dLAN (≤ 5 lx), compromised circadian function has been shown experimentally through suppressed night-time melatonin levels (14,15), attenuated rhythms in locomotor activity (16) and cardiovascular parameters (14), and altered clock gene oscillations (17).…”

Section: Introductionmentioning

confidence: 99%

Dim Light at Night Impairs Daily Variation of Circulating Immune Cells and Renal Immune Homeostasis

et al. 2021

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Dim light at night (dLAN) has become a pervasive part of the modern world, and growing evidence shows its association with increased health risks. Though this link is attributed to a disturbed circadian clock, the underlying mechanisms that can explain how circadian disruption from dLAN causes negative health effects remain unclear. Here, we exposed rats to a light–dark cycle (12:12 h) with low-intensity light at night (~2 lx) for 2 and 5 weeks and explored the steady-state pattern of circulating immune cells and renal immune-related markers, which are well controlled by the circadian clock. After 5 weeks, dLAN impaired the daily variation in several types of white blood cells, especially monocytes and T cells. Two-week dLAN caused a reduction in blood monocytes and altered gene expression of macrophage marker Cd68 and monocyte-attracting chemokine Ccl2 in the kidney. Interestingly, dLAN decreased renal 3-nitrotyrosine levels and resulted in up-regulation of the main endogenous antioxidant pathways, indicating a disturbance in the renal redox balance and an activation of compensatory mechanisms. These effects paralleled the altered renal expression of the molecular clock components and increased plasma corticosterone levels. Together, our results show that chronic exposure to dLAN weakened the circadian control of daily variation of circulating immune cells and disturbed renal immune and redox homeostasis. Consequences of this dLAN-disturbed immune balance on the ability of the immune system to cope with other challenges should by clarified in further studies.

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Section: Introductionmentioning

confidence: 99%

Dim Light at Night Impairs Daily Variation of Circulating Immune Cells and Renal Immune Homeostasis

et al. 2021

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“…Moreover, artificial light is a potent circadian rhythm disruptor that reduces melatonin levels with serious consequences. [177][178][179][180] POC measurements of tryptophan and melatonin levels could enable the early diagnosis of circadian disruption-related physiological and psychological disorders. In addition, sensing both melatonin and tryptophan in real-time might provide key insights into their role in immunomodulation, inflammatory disease, and inflammatory responses to pandemic diseases such as COVID-19.…”

Section: Challenges and Future Perspectivesmentioning

confidence: 99%

Recent Advances in Electrochemical and Optical Sensors for Detecting Tryptophan and Melatonin

Khan¹,

Hong²,

Lee³

et al. 2021

IJN

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Tryptophan and melatonin are pleiotropic molecules, each capable of influencing several cellular, biochemical, and physiological responses. Therefore, sensitive detection of tryptophan and melatonin in pharmaceutical and human samples is crucial for human wellbeing. Mass spectrometry, high-performance liquid chromatography, and capillary electrophoresis are common methods for both tryptophan and melatonin analysis; however, these methods require copious amounts of time, money, and manpower. Novel electrochemical and optical detection tools have been subjects of intensive research due to their ability to offer a better signal-to-noise ratio, high specificity, ultra-sensitivity, and wide dynamic range. Recently, researchers have designed sensitive and selective electrochemical and optical platforms by using new surface modifications, microfabrication techniques, and the decoration of diverse nanomaterials with unique properties for the detection of tryptophan and melatonin. However, there is a scarcity of review articles addressing the recent developments in the electrochemical and optical detection of tryptophan and melatonin. Here, we provide a critical and objective review of high-sensitivity tryptophan and melatonin sensors that have been developed over the past six years (2015 onwards). We review the principles, performance, and limitations of these sensors. We also address critical aspects of sensitivity and selectivity, limit and range of detection, fabrication process and time, durability, and biocompatibility. Finally, we discuss challenges related to tryptophan and melatonin detection and present future outlooks.

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“…While this statement does not necessarily preclude unnamed factors from influencing adolescent fatigue, it could be interpreted in this way. This is problematic because there is a complex interplay between developmental factors and environmental cues that affect the circadian rhythm (Lee & Kim, 2019). These environmental cues (or zeitgebers) include modifiable lifestyle factors such as natural and artificial light exposure (Roenneberg & Merrow, 2007), some of which can be adjusted for improved functioning at different stages of human development.…”

Section: Critical Analysis Of Neuromyth Itemsmentioning

confidence: 99%

Measuring Educational Neuromyths: Lessons for Future Research

Sullivan

Hughes

Gilmore

2021

Mind Brain and Education

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Educational neuromyths are incorrect ideas about the brain and learning. These ideas pose a risk if they impact learner outcomes. The concern about neuromyths has spurred global research, including teacher surveys about their identification. If such research leads to corrective strategies, the potential beneficiaries are teachers, students, and the field of educational neuroscience itself. This research relies on accurate neuromyth measures, and yet the topic of measurement has been largely ignored. In this review, we focus on key measurement issues surrounding the assessment of neuromyths, and we consider measurement improvements. We show that the framing of items, both the fact and neuromyth, must be improved in future research. These changes are vital to realize the potential benefit of educational neuromyth research.

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Light and Life at Night as Circadian Rhythm Disruptors

Cited by 16 publications

References 120 publications

Dim Light at Night Impairs Daily Variation of Circulating Immune Cells and Renal Immune Homeostasis

Dim Light at Night Impairs Daily Variation of Circulating Immune Cells and Renal Immune Homeostasis

Recent Advances in Electrochemical and Optical Sensors for Detecting Tryptophan and Melatonin

Measuring Educational Neuromyths: Lessons for Future Research

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