This is a correlational research related to the multiple correlation between metacognitive skills and creative thinking skills with students' cognitive learning results. This research aimed at investigating the contribution of metacognitive skills and creative thinking skills simultaneously on the cognitive learning results of 226 senior high school science students of Kupang, Indonesia. Metacognitive skills and creative thinking skills were measured integrated with cognitive test. The assessment of metacognitive skill, creative thinking skill, and cognitive learning results developed was validated before being used. The results of the research showed that metacognitive skills and creative thinking skill simultaneously had a high contribution on students' cognitive learning results as much as 62.78%. Metacognitive skills had a higher contribution to cognitive learning results as much as 50.26%, while the contribution of creative thinking skill was 12.52%. Based on this result, teachers need to empower students' metacognitive skills and creative thinking skills in learning because both thinking skills are required in 21st century.