Light chain 3 immunoexpression in psoriasis

Samaka, Rehab M; Marae, Alaa; Faried, Manar A.; Bazid, Heba A. S.

doi:10.1080/15321819.2021.2018708

Cited by 2 publications

(2 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recent studies have revealed that mutations in the autophagy regulator genes ATG16L1 and AP1S3 are associated with psoriasis (69,70). The connection between autophagy dysfunction and psoriasis pathogenesis was further verified by the altered expression of autophagy-related proteins in psoriatic skin, such as ATG5, ATG7, Beclin1, LC3, and p62 (71)(72)(73)(74)(75).…”

Section: Psoriasismentioning

confidence: 95%

“…LC3 expression was downregulated or even absent in psoriasis lesional skin epidermis, negatively correlating with the mean thickness of the epidermis, indicating the impairment or blockade of autophagy in psoriasis ( 74 , 78 , 79 ). Controversially, several other studies indicated the elevated expression of LC3 and other autophagy-related factors including ATG5 and ATG7, which may point to the induction of autophagy ( 72 , 75 , 80 ). It was speculated that the increased autophagosome formation could be a compensatory mechanism for reduced autophagic degradation activity, as evidenced by the accumulation of p62 and the decline of lysosome protease activity in patients with psoriasis, leading to parakeratosis in psoriasis ( 75 , 78 , 79 ).…”

Section: Autophagy In Skin Autoimmune Disordersmentioning

confidence: 99%

See 1 more Smart Citation

The multifaceted role of autophagy in skin autoimmune disorders: a guardian or culprit?

Lin,

Wu,

Yang

et al. 2024

Front. Immunol.

View full text Add to dashboard Cite

Autophagy is a cellular process that functions to maintain intracellular homeostasis via the degradation and recycling of defective organelles or damaged proteins. This dynamic mechanism participates in various biological processes, such as the regulation of cellular differentiation, proliferation, survival, and the modulation of inflammation and immune responses. Recent evidence has demonstrated the involvement of polymorphisms in autophagy-related genes in various skin autoimmune diseases. In addition, autophagy, along with autophagy-related proteins, also contributes to homeostasis maintenance and immune regulation in the skin, which is associated with skin autoimmune disorders. This review aims to provide an overview of the multifaceted role of autophagy in skin autoimmune diseases and shed light on the potential of autophagy-targeting therapeutic strategies in dermatology.

show abstract

Section: Psoriasismentioning

confidence: 95%

Section: Autophagy In Skin Autoimmune Disordersmentioning

confidence: 99%

The multifaceted role of autophagy in skin autoimmune disorders: a guardian or culprit?

Lin,

Wu,

Yang

et al. 2024

Front. Immunol.

View full text Add to dashboard Cite

show abstract

Mechanisms of autophagy and their implications in dermatological disorders

Xue,

Lin,

Chen

et al. 2024

Front. Immunol.

View full text Add to dashboard Cite

Autophagy is a highly conserved cellular self-digestive process that underlies the maintenance of cellular homeostasis. Autophagy is classified into three types: macrophage, chaperone-mediated autophagy (CMA) and microphagy, which maintain cellular homeostasis through different mechanisms. Altered autophagy regulation affects the progression of various skin diseases, including psoriasis (PA), systemic lupus erythematosus (SLE), vitiligo, atopic dermatitis (AD), alopecia areata (AA) and systemic sclerosis (SSc). In this review, we review the existing literature focusing on three mechanisms of autophagy, namely macrophage, chaperone-mediated autophagy and microphagy, as well as the roles of autophagy in the above six dermatological disorders in order to aid in further studies in the future.

show abstract

Light chain 3 immunoexpression in psoriasis

Cited by 2 publications

References 26 publications

The multifaceted role of autophagy in skin autoimmune disorders: a guardian or culprit?

The multifaceted role of autophagy in skin autoimmune disorders: a guardian or culprit?

Mechanisms of autophagy and their implications in dermatological disorders

Contact Info

Product

Resources

About