Light chain isotype‐associated suppression of normal plasma cell numbers in patients with multiple myeloma

Abstract

The number of plasma cells in the lamina propria of the gut has been assessed in patients with multiple myeloma and other B-cell neoplasms. The total number of these plasma cells was reduced in most patients with myelomatosis and one-third of patients with lymphoplasmacytoid tumours. This reduction was not, however, seen in patients with other neoplasms of B-cell origin, although hypogammaglobulinaemia was common to all groups of patients. The depletion of gut plasma cell numbers was not uniform in myelomatosis patients. They showed selective loss of plasma cells with the same light chain isotype as that produced by the neoplastic clone.

Light chain isotype associated suppression of surface immunoglobulin expression on peripheral blood lymphocytes in myeloma during plateau phase

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Light chain isotype suppression in multiple myeloma has been reported in the plasma cells of the lamina propria of the gut (Leonard et al, 1979). In this paper we present further evidence of systemic suppresssion of the light chain isotype of the paraprotein expressed on normal peripheral blood Iymphocytes in myeloma.

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Hairy-cell leukaemia: an immunoperoxidase study of paraffin-embedded tissues.

“…This finding contrasts with those in myeloma, where intestinal plasma cells with the light-chain type of the myeloma cells are reduced in number (Leonard et al, 1979). Our results are therefore in accord with the fact that HCL, unlike myeloma, is not usually associated with immuneparesis (Golomb et al, 1978;Turner and Kjeldsberg, 1978).…”

Fluorescence in situ hybridization analysis of aneuploidization patterns in monoclonal gammopathy of undetermined significance versus multiple myeloma and plasma cell leukemia

“…For many years considerable evidence has existed on the heterogeneous intratumoral cytogenetic nature of plasma cell disorders, 34 and many reported cases have illustrated the existence of periods of clonal competition 35,36 before proliferative advantage is reached by one clone. 37 In line with these observations, cases also have been reported in which transition of MGUS into active MM was associated with the expansion of a new clone carrying identical idiotypic determinants to those of the original PC clone.…”