The semileptonic decays of heavy spin-1/2, Ξ b(c) and Ξ ′ b(c) baryons to the light spin-1/2, Ξ and Σ baryons are investigated in the framework of light cone QCD sum rules. In particular, using the most general form of the interpolating currents for the heavy baryons as well as the distribution amplitudes of the Ξ and Σ baryons, we calculate all form factors entering the matrix elements of the corresponding effective Hamiltonians in full QCD. Having calculated the responsible form factors, we evaluate the decay rates and branching fractions of the related transitions. PACS number(s): 11.55. Hx, 13.30.Ce, 14.20.Mr, 14.20 Such an experimental progress stimulates the theoretical studies on properties of the heavy baryons as well as their electromagnetic, weak and strong transitions. The mass spectrum of the heavy baryons has been studied using various methods including heavy quark effective theory [2], QCD sum rules [3][4][5][6] and some other phenomenological models [7][8][9][10][11][12]. Some electromagnetic properties of the heavy baryons and their radiative decays have been investigated in different frameworks in [6,[13][14][15][16][17][18][19][20][21][22][23][24]. The strong decays of the heavy baryons have also been in the focus of much attention, theoretically (see for instance [25][26][27] and references therein).However, the weak and semileptonic decays of heavy baryons are very important frameworks not only in obtaining information about their internal structure, precise calculation of the main ingredients of standard model (SM) such as Kabbibbo-Kobayashi-Maskawa (CKM) matrix elements and answering to some fundamental questions like nature of the CP violation, but also in looking for new physics beyond the SM. The loop level semileptonic transitions of the heavy baryons containing single heavy quark to light baryons induced by the flavor changing neutral currents (FCNC) are useful tools, for instance, to look for the supersymmetric particles, light dark matter, fourth generation of the quarks and extra dimensions etc. [28,29]. Some semileptonic decay channels of the heavy baryons have been previously investigated in different frameworks (see for instance [30][31][32][33][34][35][36][37][38] and references therein).The present work deals with the semileptonic decays of heavy Ξ b(c) and Ξ ′ b(c) baryons to the light Ξ and Σ baryons. The considered channels are either at loop level described by twelve form factors in full QCD or at tree level analyzed by six form factors entering the transition matrix elements of the corresponding low energy Hamiltonian. Here, we should mention that by the "full QCD" we refer to the QCD theory without any approximation like heavy quark effective theory (HQET) so we take the mass of heavy quarks finite. In HQET approximation, the number of form factors describing the considered transitions reduce to only two form factors [39,40]. The considered processes take place in low energies far from the perturbative region, so to calculate the form factors as the main ingredie...