The key to developing a new type of liquid crystal display (LCD) lighting is to balance light quality with high light efficiency, and the light diffusion plate is an indispensable part of LCD to achieve different light extraction efficiency and light uniformity. In addition, the addition of quantum-dots (QDs) further improves the light transmittance and optical conversion efficiency of the light diffusion plate. In this paper, the surface engineering method was used to prepare QDs composites to improve the stability of QDs diffusion plate under high temperature and humidity. This paper briefly introduced the light diffusion plate, and then discusses the preparation of the QDs composites and the injection molding process of the QDs diffusion plate. Finally, the QDs diffusion plate was assembled into a backlight module, and its stability was tested at 60℃ and 85% relative humidity (RH). The experimental results show that the spectra and external quantum efficiency (EQE) of the QDs diffusion plate do not change significantly after long time storage at high temperature and humidity. This experiment improved the stability of QDs diffusion plate and lays a foundation for the subsequent large-scale production.