Light-Driven Sodium Pump as a Potential Tool for the Control of Seizures in Epilepsy

Trofimova, Alina M.; Amakhin, Dmitry V.; Postnikova, Tatyana Y.; Tiselko, Vasilii S.; Alekseev, Alexey; Podoliak, Elizaveta; Gordeliy, Valentin I.; Chizhov, Anton V.; Zaitsev, Aleksey V.

doi:10.1007/s12035-023-03865-z

Cited by 3 publications

(1 citation statement)

References 73 publications

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“…Transection of Schaffer collaterals, which connect the hippocampal CA3 and CA1 areas, can restore ictal activity in the entorhinal cortex [45,55]. Moreover, low-frequency electrical or optogenetic stimulation of the CA3 or CA1 regions can successfully suppress ictal activity in the entorhinal cortex [61,65,66]. The anti-ictogenic effect of the CA3 area is a characteristic found in adult animals.…”

Section: Discussionmentioning

confidence: 99%

Morphological and Functional Alterations in the CA1 Pyramidal Neurons of the Rat Hippocampus in the Chronic Phase of the Lithium-Pilocarpine Model of Epilepsy

Postnikova,

Diespirov,

Malkin

et al. 2024

Preprint

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Epilepsy is known to cause alterations in neural networks. However, many details of these changes remain poorly understood. The objective of this study was to investigate changes in the properties of hippocampal CA1 pyramidal neurons and their synaptic inputs in a rat lithium-pilocarpine model of epilepsy. In the chronic phase of the model, we found a marked loss of pyramidal neurons in the CA1 area. However, the membrane properties of the neurons remained essentially unal-tered. The results of the electrophysiological and morphological studies indicate that the direct pathway from the entorhinal cortex to CA1 neurons is reinforced in epileptic animals, whereas the inputs to them from CA3 are either unaltered or even diminished. In particular, the dendritic spine density in the str. lacunosum moleculare, where the direct pathway from the entorhinal cortex ter-minates, was found to be 2.5 times higher in epileptic rats than in control rats. Furthermore, the summation of responses upon stimulation of the temporoammonic pathway was enhanced by approximately twofold in epileptic rats. This enhancement is believed to be a significant con-tributing factor to the heightened epileptic activity observed in the entorhinal cortex of epileptic rats using an ex vivo 4-aminopyridine model.

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Section: Discussionmentioning

confidence: 99%

Morphological and Functional Alterations in the CA1 Pyramidal Neurons of the Rat Hippocampus in the Chronic Phase of the Lithium-Pilocarpine Model of Epilepsy

Postnikova,

Diespirov,

Malkin

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

Recent advances and current status of gene therapy for epilepsy

Cai,

Gao,

Zhang

et al. 2024

World J Pediatr

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Morphological and Functional Alterations in the CA1 Pyramidal Neurons of the Rat Hippocampus in the Chronic Phase of the Lithium–Pilocarpine Model of Epilepsy

Postnikova,

Diespirov,

Malkin

et al. 2024

IJMS

View full text Add to dashboard Cite

Epilepsy is known to cause alterations in neural networks. However, many details of these changes remain poorly understood. The objective of this study was to investigate changes in the properties of hippocampal CA1 pyramidal neurons and their synaptic inputs in a rat lithium–pilocarpine model of epilepsy. In the chronic phase of the model, we found a marked loss of pyramidal neurons in the CA1 area. However, the membrane properties of the neurons remained essentially unaltered. The results of the electrophysiological and morphological studies indicate that the direct pathway from the entorhinal cortex to CA1 neurons is reinforced in epileptic animals, whereas the inputs to them from CA3 are either unaltered or even diminished. In particular, the dendritic spine density in the str. lacunosum moleculare, where the direct pathway from the entorhinal cortex terminates, was found to be 2.5 times higher in epileptic rats than in control rats. Furthermore, the summation of responses upon stimulation of the temporoammonic pathway was enhanced by approximately twofold in epileptic rats. This enhancement is believed to be a significant contributing factor to the heightened epileptic activity observed in the entorhinal cortex of epileptic rats using an ex vivo 4-aminopyridine model.

show abstract

Light-Driven Sodium Pump as a Potential Tool for the Control of Seizures in Epilepsy

Cited by 3 publications

References 73 publications

Morphological and Functional Alterations in the CA1 Pyramidal Neurons of the Rat Hippocampus in the Chronic Phase of the Lithium-Pilocarpine Model of Epilepsy

Morphological and Functional Alterations in the CA1 Pyramidal Neurons of the Rat Hippocampus in the Chronic Phase of the Lithium-Pilocarpine Model of Epilepsy

Recent advances and current status of gene therapy for epilepsy

Morphological and Functional Alterations in the CA1 Pyramidal Neurons of the Rat Hippocampus in the Chronic Phase of the Lithium–Pilocarpine Model of Epilepsy

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