Light-emitting diode-based multiwavelength diffuse optical tomography system guided by ultrasound

Yuan, Guangqian; Alqasemi, Umar; Chen, Aaron; Yang, Yi; Zhu, Quing

doi:10.1117/1.jbo.19.12.126003

Cited by 7 publications

(4 citation statements)

References 30 publications

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“…Despite the considerable size of DOT instruments and the slow data collection process, ongoing research work aims to lower instrument costs by incorporating Light-Emitting Diodes (LEDs) and photodetectors [43][44][45]. Furthermore, DOT is being explored as a point-of-care imaging system [46], with educational applications to teach students about optical medical imaging systems [47].…”

Section: Challenges and Future Scopementioning

confidence: 99%

Near-infrared Spectroscopy for Brain and Breast Imaging

Buckley

2023

Preprint

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Near-infrared spectroscopy (NIRS) has become a key modality in medical imaging, finding application in both brain and breast imaging. This paper discusses the current trends in NIRS for brain and breast imaging, exploring advances in multi-modal integration with modalities such as functional magnetic resonance imaging (fMRI) and electroencephalography (EEG). Challenges related to spatial resolution, depth sensitivity, and the impact of extracerebral tissues on signal specificity are examined. In addition, ongoing efforts to enhance hemodynamic measurements’ quantitative accuracy. Challenges, including limited spatial resolution and tissue heterogeneity, are discussed. The discussion extends to diffuse optical tomography and ongoing instrumentation development, clinical trials and studies validating NIRS diagnostic efficacy in breast imaging. The paper emphasizes the need for standardization, integration into routine clinical practice, and motivates for future work.

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Section: Challenges and Future Scopementioning

confidence: 99%

Near-infrared Spectroscopy for Brain and Breast Imaging

Buckley

2023

Preprint

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“…The DOT instruments are big and data collection is slow. Researchers are working to reduce instrument costs by implementing LEDs and photodetectors [49][50][51]. DOT can also be used as an imaging system at point-of-care [37,52,53].…”

Section: Challengesmentioning

confidence: 99%

Breast Cancer Imaging Using Light: Ancient, History and Current State

Walker

2023

Preprint

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Breast cancer is a global health concern, necessitating continuous advancements in diagnostic medical imaging technologies for early detection and improvement of treatment. This paper presents an overview of the past, present and future of breast cancer imaging using light and some results from the current studies. The paper specifically presents the role of Diffuse Optical Tomography (DOT) in breast cancer imaging. Conventional methods, such as X-ray mammography, face limitations. Diffuse Optical Tomography, a non-invasive light-based imaging modality can provide quantitative descriptive and architectural information about breast tissue. The paper discusses the key challenges and recent developments in breast cancer imaging using DOT to overcome some key challenges. This paper aims to contribute to the understanding of the evolving technological landscape in breast cancer imaging using light for improving early detection and patient outcomes.

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“…Optical detectors provide exceptionally high sensitivity, which is exceptional for detecting low-concentration molecular targeting agents within tissues. There are several stable optical fluorescent molecular reporters [3], [4]. Optical scans of animals are largely done as a two-dimensional and semiquantitative imaging, because the scattering of light alters the signal sufficiently to make the imaging non-comparable between animals.…”

Section: Introductionmentioning

confidence: 99%

Prototype dual-channel fluorescence/transmission optical tomography system for quantification of capillary permeability and porphyrin production

Kulkarni,

Reed,

Jiang

et al. 2024

Molecular-Guided Surgery: Molecules, Devices, and Applications X

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Fluorescence optical tomography systems have been invented to directly measure several deep tissue features. While the highly scattered nature of the signal degrades spatial resolution, this scattering process also dramatically increases the optical path length and thereby amplifies the signal sensitivity to features such as capillaries and cells, suppressing the dominance of major blood vessels. The potential for high optical contrast with centimeter-level penetration into tissue motivates sampling (i) capillary leakage with a temporal sampling of indocyanine green (ICG); (ii) mitochondrial activity with protoporphyrin IX (PpIX) intensity, and (iii) oxygen metabolism sensing with delayed fluorescence of PpIX. In this work, the single-channel prototype of an optical fiber-based tomography system was developed for these purposes. The system was comprised of two sources of laser diodes, at 633 nm and 780 nm wavelengths, two avalanche photodiode detectors, a DAQ I/O card as a control and data collection unit, and fiber cables with filter blocks, all run via LabView control. The detection fiber channels included a notch filter in each arm, at 633nm and 750nm wavelengths that act as a band stop filter for these wavelengths. Fiber cables deliver and receive light from the tissue, enabling a closed-loop passive switching system. This design has a dual-purpose channel fiber system that makes it possible to just electronically switch between sequential measurement of indocyanine green (ICG) excitation (785 nm) and protoporphyrin IX (PpIX) excitation (635 nm) without any optical component movements, while transmission of the excitation signal is implicitly measured at the opposite detector. The fluorescence-to-transmission ratio data eliminates issues of fiber coupling or tissue transmission variations. The system was validated for linearity of response in relevant biological concentration ranges for each fluorophore. Also, in vivo animal studies were carried out on a mouse to see the reliability of the system at capturing the temporal ICG kinetics. This single design of dual-channel detection is a prototype for what will be a multi-fiber tomography system that can measure the intrinsic properties of tissue coupled with ultrasound imaging.

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Light-emitting diode-based multiwavelength diffuse optical tomography system guided by ultrasound

Cited by 7 publications

References 30 publications

Near-infrared Spectroscopy for Brain and Breast Imaging

Near-infrared Spectroscopy for Brain and Breast Imaging

Breast Cancer Imaging Using Light: Ancient, History and Current State

Prototype dual-channel fluorescence/transmission optical tomography system for quantification of capillary permeability and porphyrin production

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