Light-Induced Acid Generation on a Gatekeeper for Smart Nitric Oxide Delivery

Yung

Journal of Controlled Release

et al. 2017

Self Cite

173

119

Chemotherapeutic drugs have made significant contributions to anticancer therapy, along with other therapeutic methods including surgery and radiotherapy over the past century. However, multidrug resistance (MDR) of cancer cells has remained as a significant obstacle in the achievement of efficient chemotherapy. Recently, there has been increasing evidence for the potential function of nitric oxide (NO) to overcome MDR. NO is an endogenous and biocompatible molecule, contrasting with other potentially toxic chemosensitizing agents that reverse MDR effects, which has raised expectations in the development of efficient therapeutics with low side effects. In particular, nanoparticle-based drug delivery systems not only facilitate the delivery of multiple therapeutic agents, but also help bypass MDR pathways, which are conducive for the efficient delivery of NO and anticancer drugs, simultaneously. Therefore, this review will discuss the mechanism of nitric oxide (NO) in overcoming MDR and recent progress of combined NO and drug delivery systems.

Section: Progress Of Combined No and Drug Delivery Systemsmentioning

confidence: 99%

Section: Conclusion and Perspectivementioning

confidence: 99%

Combination of nitric oxide and drug delivery systems: tools for overcoming drug resistance in chemotherapy

Yung

Journal of Controlled Release

et al. 2017

Self Cite

173

119

“…An optimal NO delivery system should have high loading capacity, prolonged time release, and low cytotoxicity. 89,90 To that end, a pH- and light-responsive gatekeeper system was designed to modulate a spatiotemporal NO release for corneal wound-healing application. 90 In another study, NO-releasing poly(lactic- co -glycolic acid) (PLGA)–polyethylenimine (PEI) nanoparticles were synthesized for assessment of healing activity in methicillin-resistant Staphylococcus aureus (MRSA) infected wounds.…”

Section: Nanostructures As Carriers Of Therapeutic Agentsmentioning

confidence: 99%

Nanotechnology-Driven Therapeutic Interventions in Wound Healing: Potential Uses and Applications

et al. 2017

The chronic nature and associated complications of nonhealing wounds have led to the emergence of nanotechnology-based therapies that aim at facilitating the healing process and ultimately repairing the injured tissue. A number of engineered nanotechnologies have been proposed demonstrating unique properties and multiple functions that address specific problems associated with wound repair mechanisms. In this outlook, we highlight the most recently developed nanotechnology-based therapeutic agents and assess the viability and efficacy of each treatment, with emphasis on chronic cutaneous wounds. Herein we explore the unmet needs and future directions of current technologies, while discussing promising strategies that can advance the wound-healing field.

“…Controllable NO release from mesopores could be achieved by rational design of gatekeepers, which have been extensively explored for on‐demand drug releasing from mesopores . On this ground, calcium phosphate (CaP) nanoparticles, as a acidity‐responsive decomposition nanovalves, were capped onto the surface of mesopores . In addition, 2‐introbenzaldehyde ( o ‐NBA), as a pH‐jump reagent, was loaded into the mesopores, which was activated by light irradiation to lower the pH of surrounding environment.…”

Section: Nitric Oxide (No)‐generating Ggnsmentioning

confidence: 99%

Gas‐Generating Nanoplatforms: Material Chemistry, Multifunctionality, and Gas Therapy

2018

The fast advances of theranostic nanomedicine enable the rational design and construction of diverse functional nanoplatforms for versatile biomedical applications, among which gas-generating nanoplatforms (GGNs) have emerged very recently as unique theranostic nanoplatforms for broad gas therapies. Here, the recent developments of the rational design and chemical construction of versatile GGNs for efficient gas therapies by either exogenous physical triggers or endogenous disease-environment responsiveness are reviewed. These gases involve some therapeutic gases that can directly change disease status, such as oxygen (O ), nitric oxide (NO), carbon monoxide (CO), hydrogen (H ), hydrogen sulfide (H S) and sulfur dioxide (SO ), and other gases such as carbon dioxide (CO ), dl-menthol (DLM), and gaseous perfluorocarbon (PFC) for supplementary assistance of the theranostic process. Abundant nanocarriers have been adopted for gas delivery into lesions, including poly(d,l-lactic-co-glycolic acid), micelles, silica/mesoporous silica, organosilica, MnO , graphene, Bi Se , upconversion nanoparticles, CaCO , etc. Especially, these GGNs have been successfully developed for versatile biomedical applications, including diagnostic imaging and therapeutic use. The biosafety issue, challenges faced, and future developments on the rational construction of GGNs are also discussed for further promotion of their clinical translation to benefit patients.