Light-induced melatonin suppression: age-related reduction in response to short wavelength light

Herljevic, Mirela; Middleton, Benita; Thapan, Kavita; Skene, Debra J.

doi:10.1016/j.exger.2004.12.001

Cited by 145 publications

(107 citation statements)

References 30 publications

Supporting

Mentioning

103

Contrasting

Order By: Relevance

“…It would therefore only have been able to detect a change in the maximum response to light, as opposed to any change in sensitivity. A recent study of the melatonin-suppressing effects of monochromatic evening light in young and older females found no change in response to long wavelength (548 nm) visible light [33]. Another recent study that compared circadian phaseshifting responses to dim (10 lux) and bright (3,500 lux) light in young and older adults found no differences between the two age groups [3], consistent with our finding of no difference in the response to very dim light or to very bright light.…”

Section: Discussionmentioning

confidence: 95%

“…A recent study by Herljevic et al reported that melatonin suppression in older women was reduced compared with younger women in response to short wavelength (456 nm) visible light, but they found no age-related change in melatonin suppression in response to longer wavelength (548 nm) light [33]. That finding is of interest due to the fact that the circadian system of humans and other mammals is most sensitive to shorter wavelengths of visible light [7;45;56], and the specialized retinal ganglion cells that serve as the primary circadian photoreceptors [5;30] have a peak sensitivity in that same range.…”

Section: Discussionmentioning

confidence: 96%

See 1 more Smart Citation

Decreased sensitivity to phase-delaying effects of moderate intensity light in older subjects

Duffy

Zeitzer

Czeisler

2007

Neurobiology of Aging

113

View full text Add to dashboard Cite

Aging is associated with a change in the relationship between the timing of sleep and circadian rhythms, such that the rhythms occur later with respect to sleep than in younger adults. To investigate whether a difference in the phase-delaying response to evening light contributes to this, we conducted a 9-day inpatient study in 10 healthy older (≥ 65 y.o.) subjects. We assessed circadian phase in a constant routine, exposed each subject to a 6.5-h broad spectrum light stimulus beginning in the early biological night, and reassessed circadian phase. The stimuli spanned a range from very dim (~2 lux) to very bright (~8,000 lux) indoor light. We found a significant dose-response relationship between illuminance and the phase shift of the melatonin rhythm, with evidence that sensitivity, but not the maximal response to light, differed from that of younger adults. These findings suggest an age-related reduction in the phase-delaying response to moderate light levels. However, our findings alone do not explain the altered phase relationship between sleep and circadian rhythms associated with aging.

show abstract

Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 96%

Decreased sensitivity to phase-delaying effects of moderate intensity light in older subjects

Duffy

Zeitzer

Czeisler

2007

Neurobiology of Aging

113

View full text Add to dashboard Cite

show abstract

“…The protocol used was similar to that previously described (Thapan et al, 2001;Herljevic et al, 2005;Revell and Skene, 2007 sessions; the remaining two sessions were baseline, no-light conditions. Data from two of the light conditions tested during this study protocol were not applicable to the hypotheses tested here and are thus not presented.…”

Section: In-laboratory Protocolmentioning

confidence: 99%

Predicting Human Nocturnal Nonvisual Responses to Monochromatic and Polychromatic Light With a Melanopsin Photosensitivity Function

Revell

Barrett

Schlangen

et al. 2010

Chronobiology International

View full text Add to dashboard Cite

The short-wavelength (blue) light sensitivity of human non-visual responses is recognised as being melanopsin-based. However, whether melanopsin is the sole factor in determining the efficacy of a polychromatic light source in driving non-visual responses remains to be established. Monochromatic (λ max 437, 479 and 532 nm) and polychromatic (colour temperature: 4000 K and 17000 K) light stimuli were photon matched for their predicted ability to stimulate melanopsin, and their capacity to affect nocturnal melatonin levels, auditory reaction time and subjective alertness and mood was assessed.Young, healthy male participants aged 18 -35 years (23.6 ± 3.6 yrs; mean ± SD; n = 12) participated in 12 overnight sessions that included an individually timed 30 min light stimulus on the rising limb of the melatonin profile. At regular intervals before, during and after the light stimulus subjective mood and alertness were verbally assessed, blood samples were taken for analysis of plasma melatonin levels and an auditory reaction time task (psychomotor vigilance task: PVT) was performed. Proc GLM repeated measures ANOVA analysis revealed that significantly lower melatonin suppression was observed with the polychromatic light conditions (4000 K and 17000 K) compared to the 'melanopsin photonmatched' monochromatic light conditions (p < 0.05). In contrast, whilst subjective alertness significantly increased across the course of the light exposure it was significantly lower under the 479 nm monochromatic light condition compared to the 437 and 532 nm monochromatic and both polychromatic light conditions. The demonstration that the melatonin suppression response to polychromatic light was significantly lower than predicted by the melanopsin photosensitivity function suggests that this function is not the sole consideration when trying to predict the efficacy of broadband lighting. The different spectral sensitivity of the subjective alertness and melatonin suppression responses may imply a differential involvement of the cone photopigments. An analysis of the photon densities in specific wavelength bands for the polychromatic lights used in this and our previous study suggests that the spectral composition of a polychromatic light source, and particularly the very short wavelength content, may be critical in determining response magnitude for the non-visual effects of nocturnal light.4

show abstract

“…Within the marks that have circadian rhythms, such as sleep and waking, rectal temperature, and cortisol, the secretion rhythm of melatonin is said to be the least effected by the actions other than those of the biological clock in SCN. Because there are basic findings regarding multiple factors of the effects of light on melatonin secretion, such as action spectrum 22)23) , the dose response relation with light intensity 22)23) , duration of exposure to light 30) 31) , pupil reflex 32) , and age 33) , they are considered appropriate marks when modeling the influence of light on living organisms. In many reports that covered the influence of light on melatonin secretion, mydriatics are used and pupil diameter does not change in the experiment so the conditions differ from general environments which includes pupil reflex.…”

Section: Introductionmentioning

confidence: 99%

Prediction Model of Light-induced Melatonin Suppression

Takahashi

Katsuura

Shimomura

et al. 2011

J. Light & Vis. Env.

View full text Add to dashboard Cite

ＡＢＳＴＲＡＣＴThe prediction method of melatonin suppression values was based on previous studies related to melatonin suppression and pupil constriction. Estimated values that considered pupil constriction were larger than the actual suppression values. We focused on the pupil constriction and its correction factor to interpret the action spectrum for the properties of the melatonin suppression model. When the correction factor was used to modify the model, actual suppression values were almost completely predictable. These factors suggest that it might be possible to explain the indescribable results.

show abstract

Light-induced melatonin suppression: age-related reduction in response to short wavelength light

Cited by 145 publications

References 30 publications

Decreased sensitivity to phase-delaying effects of moderate intensity light in older subjects

Decreased sensitivity to phase-delaying effects of moderate intensity light in older subjects

Predicting Human Nocturnal Nonvisual Responses to Monochromatic and Polychromatic Light With a Melanopsin Photosensitivity Function

Prediction Model of Light-induced Melatonin Suppression

Contact Info

Product

Resources

About