Light Interference (LI) as a possible stressor altering HSP70 and its gene expression levels in brain and liver tissues of Golden Spiny Mice

Ashkenazi, Lilach; Haim, Abraham

doi:10.1242/jeb.073429

Cited by 21 publications

(9 citation statements)

References 68 publications

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“…These span studies of gene expression (e.g. [41,42]), physiology (e.g. [43][44][45][46]), foraging [24,[47][48][49][50], daily movements [51][52][53][54][55], migratory behaviour (e.g.…”

Section: Individual Organismsmentioning

confidence: 99%

The biological impacts of artificial light at night: the research challenge

Gaston

Visser

Hölker

2015

Phil. Trans. R. Soc. B

404

278

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“…These span studies of gene expression (e.g. [41,42]), physiology (e.g. [43][44][45][46]), foraging [24,[47][48][49][50], daily movements [51][52][53][54][55], migratory behaviour (e.g.…”

Section: Individual Organismsmentioning

confidence: 99%

The biological impacts of artificial light at night: the research challenge

Gaston

Visser

Hölker

2015

Phil. Trans. R. Soc. B

404

278

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“…In turn this can result in changes in expression of heat shock proteins, cortisol production and immune function, and increased risk of cancer (e.g. Dauchy et al 1997; Bedrosian et al 2011, 2013; Ashkenazi and Haim 2012; Schwimmer et al 2014). This suggests that wild populations may also experience significant health impacts from ALAN.…”

Section: Effects On Terrestrial Ecosystemsmentioning

confidence: 99%

Human alteration of natural light cycles: causes and ecological consequences

et al. 2014

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Artificial light at night is profoundly altering natural light cycles, particularly as perceived by many organisms, over extensive areas of the globe. This alteration comprises the introduction of light at night at places and times at which it has not previously occurred, and with different spectral signatures. Given the long geological periods for which light cycles have previously been consistent, this constitutes a novel environmental pressure, and one for which there is evidence for biological effects that span from molecular to community level. Here we provide a synthesis of understanding of the form and extent of this alteration, some of the key consequences for terrestrial and aquatic ecosystems, interactions and synergies with other anthropogenic pressures on the environment, major uncertainties, and future prospects and management options. This constitutes a compelling example of the need for a thoroughly interdisciplinary approach to understanding and managing the impact of one particular anthropogenic pressure. The former requires insights that span molecular biology to ecosystem ecology, and the latter contributions of biologists, policy makers and engineers.

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“…According to the second potential impact mechanism, humans, being involved in night-time activities enabled by ALAN, may suffer from daily rhythms disruption, leading to increased susceptibility to various diseases, including BC (Haim & Portnov, 2013;Navara & Nelson, 2007;Stevens & Rea, 2001). According to the third potential impact mechanism, ALAN may work as a general stressor and endocrine disruptor, especially when changes in nighttime light intensity are sudden and unexpected (Ashkenazi & Haim, 2012;Haim & Portnov, 2013;Navara & Nelson, 2007;Zubidat et al, 2007). In a recent review it was also suggested that MLT is a mediator between the environment and epigenome (Haim & Zubidat, 2015), supporting the results obtained earlier by Schwimmer et al (2014).…”

Section: Introductionmentioning

confidence: 64%

Artificial Light at Night (ALAN) and breast cancer incidence worldwide: A revisit of earlier findings with analysis of current trends

Rybnikova

Haim

Portnov

2015

Chronobiology International

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In a study published in Cancer Causes & Control in 2010, Kloog with co-authors tested, apparently for the first time, the association between population-level ambient exposure to artificial light at night (ALAN) and incidence of several cancers in women from 164 countries worldwide. The study was based on 1996-2002 data and concluded that breast cancer (BC) incidence was significantly and positively associated with ALAN, while no such association was revealed for other cancer types. An open question, however, remains whether the trends revealed by Kloog and co-authors were time specific or also hold true for more recent data. Using information obtained from the GLOBOCAN, US-DMSP and World Bank's 2002 and 2012 databases, we reanalyzed the strength of association between BC incidence rates in 180 countries worldwide and ALAN, controlling for several country-level predictors, including birth rates, percent of urban population, per capita GDP and electricity consumption. We also compared BC age-standardized rates (ASRs) with multi-annual ALAN measurements, considering potentially different latency periods. Compared with the results of Kloog et al.'s analysis of the year-2002 BC-data, the association between BC and ALAN appears to have weakened overall, becoming statistically insignificant in the year 2012 after being controlled for potential confounders (t < 0.3; p > 0.5). However, when the entire sample of countries was disaggregated into geographic clusters of similarly developed countries, a positive BC-ALAN association re-emerged as statistically significant (t > 2.2; p < 0.01), helping to explain, along with other factors covered by the analysis, about 65-85% of BC ASR variability worldwide, depending on the model type. Although the present analysis reconfirms a positive BC-ALAN association, this association appeared to diverge regionally in recent years, with countries in Western Europe showing the highest levels of such association, while countries in Southeast Asia and Gulf States exhibiting relatively low BC rates against the backdrop of relatively high ALAN levels. This regional stratification may be due to additional protective mechanisms, diminishing BC risks and potentially attributed to the local diet and lifestyles.

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Light Interference (LI) as a possible stressor altering HSP70 and its gene expression levels in brain and liver tissues of Golden Spiny Mice

Cited by 21 publications

References 68 publications

The biological impacts of artificial light at night: the research challenge

The biological impacts of artificial light at night: the research challenge

Human alteration of natural light cycles: causes and ecological consequences

Artificial Light at Night (ALAN) and breast cancer incidence worldwide: A revisit of earlier findings with analysis of current trends

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