Abstract:Despite their promise, the application of growth factors in regenerative medicine is limited by their poor stability in the body, high costs of production/storage and need for localized and tightly controlled delivery to minimize adverse side effects. In this study, a unique strategy to overcome these limitations is explored based on engineered living materials (ELMs). These are an emerging class of composite materials, which contain live microorganisms that can be engineered to produce and secrete proteins in… Show more
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