Light regulation of rhodopsin distribution during outer segment renewal in murine rod photoreceptors

Rose, Kasey; Chen, Natalie; Andreev, Andrey; Chen, Jiayan; Kefalov, Vladimir J.; Chen, Jeannie

doi:10.1016/j.cub.2024.02.070

Current Biology

2024

DOI: 10.1016/j.cub.2024.02.070

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Light regulation of rhodopsin distribution during outer segment renewal in murine rod photoreceptors

Kasey Rose,

Natalie Chen,

Andrey Andreev

et al.

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2024

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The Formation and Renewal of Photoreceptor Outer Segments

Xu,

Zhao,

Kang

2024

Cells

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The visual system is essential for humans to perceive the environment. In the retina, rod and cone photoreceptor neurons are the initial sites where vision forms. The apical region of both cone and rod photoreceptors contains a light-sensing organelle known as the outer segment (OS), which houses tens of thousands of light-sensitive opsins. The OSs of photoreceptors are not static; they require rhythmic renewal to maintain normal physiological functions. Disruptions in OS renewal can lead to various genetic disorders, such as retinitis pigmentosa (RP). Understanding the patterns and molecular mechanisms of photoreceptor OS renewal remains one of the most intriguing topics in visual biology. This review aims to elucidate the structure of photoreceptor OSs, the molecular mechanisms underlying photoreceptor OS renewal, and the retinal diseases resulting from defects in this renewal process. Additionally, we will explore retinal diseases related to photoreceptor OS renewal and potential therapeutic strategies, concluding with a discussion on future research directions for OS renewal.

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The Formation and Renewal of Photoreceptor Outer Segments

Xu,

Zhao,

Kang

2024

Cells

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Light regulation of rhodopsin distribution during outer segment renewal in murine rod photoreceptors

Cited by 1 publication

References 75 publications

The Formation and Renewal of Photoreceptor Outer Segments

The Formation and Renewal of Photoreceptor Outer Segments

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