Light-responsive polymer nanoreactors: a source of reactive oxygen species on demand

Baumann, Patric; Balasubramanian, Vimalkumar; Onaca-Fischer, Ozana; Sienkiewicz, Andrzej; Palivan, Cornelia G.

doi:10.1039/c2nr32380j

Cited by 47 publications

(59 citation statements)

References 34 publications

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“…For example, by choosing the encapsulated enzymes, the nanoreactors can be used either to produce antibiotics in situ [49] or to act as an artificial organelle [50]. Encapsulated photosensitizer can be used to generate a Trojan horse like nanoreactor for application in photodynamic therapy (PDT) [51]. Trojan horse nanoreactors generating ROS (reactive oxygen species) are also being tried to target cancer cells as specific tumor targeting approaches (Fig.…”

Section: Medical Applications Of Self-assembled Structuresmentioning

confidence: 99%

Polymersomes in Nanomedicine - A Review

Zhang

2017

CNANO

117

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Background: The worldwide medicine research is dedicated towards improvement of patients' health and diseased state. The use of nanotechnology is an upcoming area which is at present, is highly focused in the filed of medicine. Continuous studies in the area have given rise to the development of a novel field called "nanomedicine" which mainly aims to open new perspective of treatments and increasing therapeutic efficacy of existing therapies. Methods:We searched Google, PubMed portals for the literature survey of the following subjects so as to get latest updated information pertaining to latest developments in the field of polymerosomes in nanomedicine. Results:In most of the recent past studies, nanomedicine has gain attention all over the world and has lead to development of new approaches for medical treatments. Some of these approaches involved solubilization, targeting of cancer medicine or application as a diagnostic tool. Polymersomes, which are artificial amphiphilic vesicles, made up of different chemical polymers, are currently being investigated for delivering various probes for imaging target tissues/ organs and cytotoxic drugs to tumor cells and also for gene therapy. In the present review, we discuss the current views on polymerosomes and their medical applications, a prominent emerging area in the field of nanomedicine. Conclusions:Advances in nanomedicine have led to the development of nano-sized polymersomes as vehicles for different medical applications.

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Section: Medical Applications Of Self-assembled Structuresmentioning

confidence: 99%

Polymersomes in Nanomedicine - A Review

Zhang

2017

CNANO

117

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“…The in vivo demonstration of this technology was done using the zebrafish and the further application in mammalian models is awaited. Recently, studies describing another interesting platform called “light-responsive polymer nanoreactors” for on demand production of ROS were reported [83,84]. The polymeric nanoparticles loaded with a photosensitizer-protein conjugate, can be triggered with an appropriate light source generating ROS as desired.…”

Section: Phototriggerable Nano Drug Delivery Platformsmentioning

confidence: 99%

Phototriggerable Liposomes: Current Research and Future Perspectives

Puri

2013

Pharmaceutics

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The field of cancer nanomedicine is considered a promising area for improved delivery of bioactive molecules including drugs, pharmaceutical agents and nucleic acids. Among these, drug delivery technology has made discernible progress in recent years and the areas that warrant further focus and consideration towards technological developments have also been recognized. Development of viable methods for on-demand spatial and temporal release of entrapped drugs from the nanocarriers is an arena that is likely to enhance the clinical suitability of drug-loaded nanocarriers. One such approach, which utilizes light as the external stimulus to disrupt and/or destabilize drug-loaded nanoparticles, will be the discussion platform of this article. Although several phototriggerable nanocarriers are currently under development, I will limit this review to the phototriggerable liposomes that have demonstrated promise in the cell culture systems at least (but not the last). The topics covered in this review include (i) a brief summary of various phototriggerable nanocarriers; (ii) an overview of the application of liposomes to deliver payload of photosensitizers and associated technologies; (iii) the design considerations of photoactivable lipid molecules and the chemical considerations and mechanisms of phototriggering of liposomal lipids; (iv) limitations and future directions for in vivo, clinically viable triggered drug delivery approaches and potential novel photoactivation strategies will be discussed.

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“…Ps remained stable inside cells after having escaped from endosomes without releasing the encapsulated compounds. 24,25,45 Therefore, it is possible that in our experiments, QDs were partially degraded inside the Ps without being released. Due to the stability of Ps in cellular conditions, degradation of QDs and background signals were dramatically lower in Ps than in liposomes.…”

Section: 44mentioning

confidence: 99%

Polymersomes containing quantum dots for cellular imaging

Camblin¹,

Detampel²,

Kettiger³

et al. 2014

IJN

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Quantum dots (QDs) are highly fluorescent and stable probes for cellular and molecular imaging. However, poor intracellular delivery, stability, and toxicity of QDs in biological compartments hamper their use in cellular imaging. To overcome these limitations, we developed a simple and effective method to load QDs into polymersomes (Ps) made of poly(dimethylsiloxane)-poly(2-methyloxazoline) (PDMS-PMOXA) diblock copolymers without compromising the characteristics of the QDs. These Ps showed no cellular toxicity and QDs were successfully incorporated into the aqueous compartment of the Ps as confirmed by transmission electron microscopy, fluorescence spectroscopy, and fluorescence correlation spectroscopy. Ps containing QDs showed colloidal stability over a period of 6 weeks if stored in phosphatebuffered saline (PBS) at physiological pH (7.4). Efficient intracellular delivery of Ps containing QDs was achieved in human liver carcinoma cells (HepG2) and was visualized by confocal laser scanning microscopy (CLSM). Ps containing QDs showed a time-and concentration-dependent uptake in HepG2 cells and exhibited better intracellular stability than liposomes. Our results suggest that Ps containing QDs can be used as nanoprobes for cellular imaging.

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Light-responsive polymer nanoreactors: a source of reactive oxygen species on demand

Cited by 47 publications

References 34 publications

Polymersomes in Nanomedicine - A Review

Polymersomes in Nanomedicine - A Review

Phototriggerable Liposomes: Current Research and Future Perspectives

Polymersomes containing quantum dots for cellular imaging

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