Light sources for PDT in dermatology

Hommel, Theresa; Szeimies, Rolf‐Markus

doi:10.1016/j.pdpdt.2017.01.034

Cited by 2 publications

(2 citation statements)

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“…Both techniques are based on the PS compound, which interacts with light, at an appropriate wavelength, and molecular oxygen, consequently generating the singlet oxygen ( 1 O 2 ) and the reactive oxygen species (ROS) . These species are responsible for causing pronounced damage of cells as well as the inactivation of main microorganisms, which are responsible for secondary infections. , Commonly, topical treatments based on PDT are local, preserve the individual from most of the side effects, , facilitate the application, and promote satisfactory acceptance . Additionally, the direct administration of the drug at the site of action protects the individual against severe pH conditions and conversion to inactive forms (first-pass hepatic metabolism). , …”

Section: Introductionmentioning

confidence: 99%

Photothermal Stimuli-Responsive Hydrogel Containing Safranine for Mastitis Treatment in Veterinary Using Phototherapy

Silva-Junior

Campanholi

Morais

et al. 2020

ACS Appl. Bio Mater.

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Safranine-O (Sf) is a photosensitizer (PS) displaying a remarkable potential for photodynamic therapy (PDT). In this work, we have used the combination of Sf with F127 Pluronic and Carbopol (C934P) to obtain a stimuliresponsive hydrogel (SR-Sf). This thermoresponsive-photoactive nanostructured system was prepared by two different methods: direct addition (DA) and solid dispersion (SD). Both SR-Sf have had their physical and chemical properties evaluated for veterinary applications, especially considering their ability to be used as a commercial product, aiming at the prophylactic or therapeutic treatment of breast gland infections. In general, the rheological and mechanical properties, as well as the sol−gel transition temperature, indicated suitable properties for using them as a topical system in veterinary (and human) applications. The ex vivo release studies showed a satisfactory permeation profile of the SR-Sf hydrogel, reaching the full length of the overall skin toward the dermis within 30 min of application (989 μm). The in vitro studies showed photodynamic inactivation using Sf-F127 with a significant reduction in isolated colonies. The in vivo case report with dairy goat demonstrated that the SR-Sf hydrogel veterinary use platform emerged as an innovative approach for the treatment of local infections without generating antibiotic residues in the milk produced.

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Section: Introductionmentioning

confidence: 99%

Photothermal Stimuli-Responsive Hydrogel Containing Safranine for Mastitis Treatment in Veterinary Using Phototherapy

Silva-Junior

Campanholi

Morais

et al. 2020

ACS Appl. Bio Mater.

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“…As a result, the emission spectrum range of UV LEDs is not as broad as that of conventional arc-lamps, and thus the need for achieving a solid-state based broadband UV light source still remains. Because of the spectral limitations of conventional UV LEDs, some applications such as UV spectrophotometry 12,13 and photodynamic therapy in dermatology 14,15 still require arc-lamps even though the arc-lamp system is impractical and inefficient due to their bulky system, heat generation and poor lifetime.…”

Section: Introductionmentioning

confidence: 99%

A broadband ultraviolet light source using GaN quantum dots formed on hexagonal truncated pyramid structures

et al. 2020

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A broadband ultraviolet light source using GaN quantum dots formed on hexagonal truncated pyramid structures Broadband ultraviolet (UV) emission has been achieved from the GaN quantum dots grown on diff erent facets of hexagonal truncated pyramidal structures. The GaN-based structures include both semipolar and polar facets, on which the intrinsic piezoelectric fi elds and the growth rates are diff erent. In addition, a strain is locally suppressed at the boundaries of the truncated pyramid structure. As a result, the emission wavelength of quantum dots on various facets and boundaries becomes quite diff erent, rendering a solid-state broadband UV light source with homogenerous intensity in a wide wavelength range.Registered charity number: 207890 rsc.li/nanoscale-advances A broadband ultraviolet light source using GaN quantum dots formed on hexagonal truncated pyramid structures † Group III-nitride semiconductor-based ultraviolet (UV) light emitting diodes have been suggested as a substitute for conventional arc-lamps such as mercury, xenon and deuterium arc-lamps, since they are compact, efficient and have a long lifetime. However, in previously reported studies, group III-nitride UV light emitting diodes did not show a broad UV spectrum range as conventional arc-lamps, which restricts their application in fields such as medical therapy and UV spectrophotometry. Here, we propose GaN quantum dots (QDs) grown on different facets of hexagonal truncated pyramid structures formed on a conventional (0001) sapphire substrate. A hexagonal truncated GaN pyramid structure includes {10 11} semipolar facets as well as a (0001) polar facet, which have intrinsically different piezoelectric fields and growth rates of GaN QDs. Consequently, we successfully demonstrated a plateau-like broadband UV spectrum ranging from $400 nm (UV-A) to $270 nm (UV-C) from the GaN QDs. In addition, at the top-edge of the truncated pyramid structure, a strain was locally suppressed compared to the center of the truncated pyramid structure. As a result, various emission wavelengths in the UV range were achieved from the GaN QDs grown on the sidewall, top-edge and top-center of hexagonal truncated pyramid structures, which ultimately provide a broadband UV spectrum with high efficiency.

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Light sources for PDT in dermatology

Cited by 2 publications

References 0 publications

Photothermal Stimuli-Responsive Hydrogel Containing Safranine for Mastitis Treatment in Veterinary Using Phototherapy

Photothermal Stimuli-Responsive Hydrogel Containing Safranine for Mastitis Treatment in Veterinary Using Phototherapy

A broadband ultraviolet light source using GaN quantum dots formed on hexagonal truncated pyramid structures

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