Light stimulation of mitochondria reduces blood glucose levels

Powner, Michael B.; Jeffery, Glen

doi:10.1002/jbio.202300521

Cited by 8 publications

(2 citation statements)

References 45 publications

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“…Glucose was not monitored in this study, but in light of previous work it is possible that 420nm and 450nm both reduced mitochondrial function resulting in reduced demand for serum glucose 13 . Although similar experiments have not been undertaken in humans, it is established that 670nm light that increases mitochondrial activity results in increased oxygen consumption and tighter regulation of serum glucose 9 . While short wavelength exposure has a signi cant and very rapid impact on human physiology, particularly heart rate and blood pressure 1 , but it remains unknown if this includes blood glucose regulation.…”

Section: Discussionmentioning

confidence: 99%

“…While short wavelengths in the solar spectrum undermine mitochondria, longer wavelengths (650nm -~900nm) positively in uence their behaviour, increasing membrane potential and ATP production that translates into improved function in animals and humans [4][5][6][7][8] . Longer wavelengths have also been shown to improve systemic physiology in humans by reducing blood glucose levels due to increased mitochondria demand for sugars 9 . The mechanism of longer wavelength in uence over mitochondria is different from that of short wavelength light absorption and is thought to be related by cytochrome C oxidase absorption in the mitochondrial respiration chain 10 .…”

Section: Introductionmentioning

confidence: 99%

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Exposure to short wavelength light absorbed by mitochondria is associated with weight gain, shifts in cytokine expression and anxiety-like behaviours.

Al-Hussaini,

Al-Onaizi,

Abed

et al. 2024

Preprint

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Mitochondria absorb short wavelengths around 420nm. This is associated with reduced ATP and restricted mobility. The 420-450nm range is a significant element of LED lighting and computer monitors. Here we expose freely moving mice to 420nm or 450nm lighting and show rapidly weight gain within a week. This may be due to reduced mitochondrial demand for circulating carbohydrates. Both groups displayed marked shifts in serum cytokines. Open field mobility was examined. The distance travelled was similar between both experimental groups and their controls. However, both experimental groups showed avoidance of central regions consistent with anxiety-like behaviours. This was significant in the 420nm group whose wavelength exposure is closer to peak mitochondrial absorbance. These data demonstrate the potential hazards of exposure to specific short wavelengths in the visual range now common in the built environment. Data are consistent with a wider literature on systemic problems arising from exposure to short wavelength light.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Exposure to short wavelength light absorbed by mitochondria is associated with weight gain, shifts in cytokine expression and anxiety-like behaviours.

Al-Hussaini,

Al-Onaizi,

Abed

et al. 2024

Preprint

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Photobiomodulation Enhances the Effect of Strength Training on Insulin Resistance Regardless of Exercise Volume in Mice Fed a High‐Fat Diet

Costa,

Silva,

Guimarães

et al. 2024

Journal of Biophotonics

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The aim was to investigate the effects of different volumes of strength training (ST) in association with photobiomodulation (PBMt) in mice fed a high‐fat diet (HFD) on insulin resistance (IR). Male Swiss albino mice were fed HFD and performed high‐ or low‐volume (one‐third) ST (3 days/week), associated with PBMt (660 nm + 850 nm; ~42 J delivered) or not (lights off). ST improved IR, lowered visceral adiposity and circulating cytokines, and increased skeletal muscle hypertrophy and mitochondrial activity. The smaller volume of ST did not interfere with the improvement in IR, mitochondrial activity, or inflammatory profile, but exerted a smaller effect on visceral adiposity and skeletal muscle hypertrophy. Association with PBMt further improved IR, regardless of ST volume, although it did not affect adiposity, mitochondrial activity, and the inflammatory profile. Interestingly, PBMt positively affected quadriceps, but attenuated gluteus maximus hypertrophy. The association with PBMt induced greater improvement than ST alone.

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The Role of Photobiomodulation to Modulate Ion Channels in the Nervous System: A Systematic Review

Zhang,

Liu

et al. 2024

Cell Mol Neurobiol

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Photobiomodulation (PBM) is a safe and effective neurotherapy that modulates cellular pathways by altering cell membrane potentials, leading to beneficial biological effects such as anti-inflammatory and neuroregenerative responses. This review compiles studies from PubMed up to March 2024, investigating the impact of light at wavelengths ranging from 620 to 1270 nm on ion channels. Out of 330 articles screened, 19 met the inclusion criteria. Research indicates that PBM can directly affect various ion channels by influencing neurotransmitter synthesis in neighboring cells, impacting receptors like glutamate and acetylcholine, as well as potassium, sodium channels, and transient receptor potential channels. The diversity of studies hampers a comprehensive meta-analysis for evaluating treatment strategies effectively. This systematic review aims to explore the potential role of optoelectronic signal transduction in PBM, studying the neurobiological mechanisms and therapeutic significance of PBM on ion channels. However, the lack of uniformity in current treatment methods underscores the necessity of establishing standardized and reliable therapeutic approaches. Graphical Abstract PBM is a promising neurotherapeutic approach with anti-inflammatory and neuroregenerative potential through its effects on cell membrane potential and ion channels. This systematic review analyzes 19 studies, revealing its influence on channel activity and emphasizing the need for standardized treatment protocols.

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Light stimulation of mitochondria reduces blood glucose levels

Cited by 8 publications

References 45 publications

Exposure to short wavelength light absorbed by mitochondria is associated with weight gain, shifts in cytokine expression and anxiety-like behaviours.

Exposure to short wavelength light absorbed by mitochondria is associated with weight gain, shifts in cytokine expression and anxiety-like behaviours.

Photobiomodulation Enhances the Effect of Strength Training on Insulin Resistance Regardless of Exercise Volume in Mice Fed a High‐Fat Diet

The Role of Photobiomodulation to Modulate Ion Channels in the Nervous System: A Systematic Review

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