Light-switchable systems for remotely controlled drug delivery

Shim, Gayong; Ko, Seungbeom; Kim, Dong-Yoon; Le, Quoc‐Viet; Park, Gyu Thae; Lee, Jaiwoo; Kwon, Taek-Hyun; Choi, Han‐Gon; Kim, Young Bong; Oh, Yu‐Kyoung

doi:10.1016/j.jconrel.2017.09.009

Cited by 65 publications

(45 citation statements)

References 77 publications

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“…The second mechanism is the photochemical liberation of PTX from endosomes into the cytoplasm. Such photochemical liberation of chemotherapeutic drugs into the cytoplasm has been previously reported 17 . Possible mechanisms of action of PDA/AM/P nanoparticles are illustrated in Fig.…”

Section: Discussionmentioning

confidence: 55%

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Safety and photochemotherapeutic application of poly(γ-glutamic acid)-based biopolymeric nanoparticle

Kim

et al. 2019

Acta Pharmaceutica Sinica B

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The safety of nanomaterials, a crucial consideration for clinical translation, is enhanced by using building blocks that are biologically nontoxic. Here, we used poly( γ -glutamic acid) ( γ -PGA) and dopamine as building blocks of polymeric nanomaterials for carrying hydrophobic anticancer drugs. The introduction of phenylalanine onto γ -PGA enabled the resulting amphiphilic derivative of γ -PGA acid to self-assemble in the presence of the anticancer drug paclitaxel (PTX) to form PTX-encapsulated micelles. The surfaces of PTX-loaded micelles were then coated with polymerized dopamine (PDA). The PDA-coated, amphiphilic γ -PGA-based micelles (AM) carrying PTX (PDA/AM/P) exerted near-infrared-responsive photothermal effects. Near-infrared irradiation of cancer cells treated with PDA/AM/P nanoparticles produced a greater anticancer effect than that observed in other treatment groups, indicating a synergistic effect. Intravenous administration of PDA/AM/P completely ablated tumors and prevented their recurrence. Notably, the in vivo safety profile of PDA/AM/P nanoparticles allowed PTX to be delivered at a 3.6-fold higher dose than was possible with PTX solubilized in surfactant, and circumvented the side effects of the surfactant. These results support the multifunctional potential of PDA/AM for the delivery of various hydrophobic drugs and imaging dyes for safe translation of nanomaterials into the clinic.

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Section: Discussionmentioning

confidence: 55%

“…The photothermal feature of PDA nanomaterial has been applied to anticancer phototherapy. PDA alone has been used to induce local hyperthermia upon irradiation with NIR 17 . In some studies, PDA has been used to coat the surfaces of gold nanorods 18 , graphene oxide nanosheets 19 , and iron oxide nanoparticles 20 .…”

Section: Introductionmentioning

confidence: 99%

Safety and photochemotherapeutic application of poly(γ-glutamic acid)-based biopolymeric nanoparticle

Kim

et al. 2019

Acta Pharmaceutica Sinica B

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“…As previously reported [55,83], changes in the size of NPs have a significant impact on biodistribution and targeting in vivo as well as on PA signals. Yang et al precisely controlled the size of perylene diimide-based semiconducting NPs by tuning the concentration of diimide molecules during self-assembly [21].…”

Section: Light-responsive Nanomedicine For Biophotonic Imagingmentioning

confidence: 55%

“…These strategies enable stable storage of drugs in NPs during blood circulation and controlled drug release only in the target tissue upon light irradiation [83,90]. Rwei et al fabricated NIR light-triggered liposomes, resulting in controlled drug release upon irradiation [34].…”

Section: Light-responsive Nanomedicine For Targeted Therapy and Drug mentioning

confidence: 99%

Light-responsive nanomedicine for biophotonic imaging and targeted therapy

Son

Yoo

et al. 2019

Advanced Drug Delivery Reviews

123

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Nanoparticles (NPs) play a key role in nanomedicine in multimodal imaging, drug delivery and targeted therapy of human diseases. Consequently, due to the attractive properties of NPs including high stability, high payload, multifunctionality, design flexibility, and efficient delivery to target tissues, nanomedicine employs various types of NPs to enhance targeting and treatment efficacy. In this review, we primarily focus on light-responsive materials, such as fluorophores, photosensitizers, semiconducting polymers, carbon structures, gold particles, quantum dots, and upconversion crystals, for their biomedical applications. Armed with these nanomaterials, NPs represent a growing potential in biophotonic imaging (luminescence, photoacoustic, surface enhanced Raman scattering, and optical coherence tomography) as well as targeted therapy (photodynamic therapy, photothermal therapy, and light-responsive drug release).

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“…Light is noninvasive, allowing instantaneous manipulation and remotely triggering of the systems with high spatiotemporal precision and accuracy . This would result in eliminating the steric hindrance effect of the action sites of bulky DNA nanostructures.…”

Section: Introductionmentioning

confidence: 99%

Photoresponsive Self‐Assembled DNA Nanomaterials: Design, Working Principles, and Applications

Tam

Zhuang

Wong

et al. 2019

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Photoresponsive DNA nanomaterials represent a new class of remarkable functional materials. By adjusting the irradiation wavelength, light intensity, and exposure time, various photocontrolled DNA‐based systems can be reversibly or irreversibly regulated in respect of their size, shape, conformation, movement, and dissociation/association. This Review introduces the most updated progress in the development of photoresponsive DNA‐based system and emphasizes their advantages over other stimuli‐responsive systems. Their design and mechanisms to trigger the photoresponses are shown and discussed. The potential application of these photon‐responsive DNA nanomaterials in biology, biomedicine, materials science, nanophotonic and nanoelectronic are also covered and described. The challenges faced and further directions of the development of photocontrolled DNA‐based systems are also highlighted.

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Light-switchable systems for remotely controlled drug delivery

Cited by 65 publications

References 77 publications

Safety and photochemotherapeutic application of poly(γ-glutamic acid)-based biopolymeric nanoparticle

Safety and photochemotherapeutic application of poly(γ-glutamic acid)-based biopolymeric nanoparticle

Light-responsive nanomedicine for biophotonic imaging and targeted therapy

Photoresponsive Self‐Assembled DNA Nanomaterials: Design, Working Principles, and Applications

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