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REPORT DATE
May 20142. REPORT TYPE
PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) 8. PERFORMING ORGANIZATION REPORT NUMBER
University of California San Francisco Dept of Epidemiology and BiostatisticsSan Francisco, CA 94143
SPONSORING / MONITORING AGENCY NAME(S) AND ADDRESS(ES) 10. SPONSOR/MONITOR'S ACRONYM(S)
U.S. Army Medical Research and Materiel CommandFort Detrick, Maryland 21702-5012
SPONSOR/MONITOR'S REPORT NUMBER(S)
DISTRIBUTION / AVAILABILITY STATEMENTApproved for Public Release; Distribution Unlimited
SUPPLEMENTARY NOTES
ABSTRACT (Enter a brief (approximately 200 words) unclassified summary of the most significant finding during the research period.)We used a large, diverse, longitudinal study of middle aged and older Americans to identify social factors that help individuals preserve functional independence in basic and instrumental ADLs as long as possible, even in the context of declining memory or severe memory impairment. As expected, we found strong associations between decreased cognitive functioning and incident ADL and IADL limitations. We also found that physical activity may help to decrease the risk of ADL and IADL limitations even among those with cognitive impairment, while smoking and depression may increase the risk of incident ADL limitations among those with cognitive impairments. This finding has critical importance for clinicians, patients, and family members of individuals with cognitive impairments or incipient dementia. By managing conventional risk factors, it may be possible to stave off dependencies, maximize quality of life, and minimize caregiver burden. This is especially important for older veterans and those with prior exposure to mild, moderate, or severe TBI, who are at elevated risk of memory loss and dementia.
SUBJECT TERMS (Key words or phrases identifying major concepts in the report)
INTRODUCTIONMemory losses are common among long-term survivors of traumatic brain injury (TBI) and TBI has been linked to increased risk of memory impairment and dementia. This is an important determinant of long-term well-being for military service men and women and their families, b...