Light transmittance of 1-piece hydrophobic acrylic intraocular lenses with surface light scattering removed from cadaver eyes

Werner, Liliana; Morris, Caleb; Liu, Erica; Stallings, Shannon; Floyd, Anne; Ollerton, Andrew; Leishman, Lisa; Bodnar, Zachary

doi:10.1016/j.jcrs.2013.05.050

Cited by 16 publications

(8 citation statements)

References 15 publications

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“…Interestingly, previous reports on light transmittance using AcrySof lenses with glistening and SSNG did not find any decrease18, 19 and seem to contradict our findings. In their studies, an integrated sphere type spectrophotometer (Lambda 35 UV/Vis spectrophotometer, PerkinElmer Inc.) was used; however, we used a double beam spectrophotometer and this may explain the difference in findings.…”

Section: Discussioncontrasting

confidence: 99%

Decreased visual acuity resulting from glistening and sub-surface nano-glistening formation in intraocular lenses: A retrospective analysis of 5 cases

Matsushima

Nagata

Katsuki

et al. 2015

Saudi Journal of Ophthalmology

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Although only a few reports of cases in which glistening and SSNG have progressed to the level of decreased visual function have been published, the likelihood is that this phenomena will increase as the severity and incidence of these inclusions have been shown to increase with time. Appropriate evaluations of visual function in such patients are needed and consideration should be given to IOL exchange in symptomatic patients.

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Section: Discussioncontrasting

confidence: 99%

Decreased visual acuity resulting from glistening and sub-surface nano-glistening formation in intraocular lenses: A retrospective analysis of 5 cases

Matsushima

Nagata

Katsuki

et al. 2015

Saudi Journal of Ophthalmology

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“…27 Staining with Coomassie blue G-250 can confirm protein removal, and, if required, proteins may be eliminated with treatment with a mixture of enzymes (subtilisin A and trypsin), a chelator (ethylenediaminetetraacetic acid), and with a solution of 0.6% sodium hypochlorite in phosphate-buffered saline; in this case, the residual stain should be removed by treating the IOL with a 0.6% sodium hypochlorite solution and then rinsing in distilled deionized water. [55][56][57] As glistening and SSNGS are temper- Gross photograph of the explanted lens in the dry state (320). (B) Light photomicrograph of the dry lens (3400).…”

Section: Methods For Iol Evaluationmentioning

confidence: 99%

“…51 Thus, the IOL analysis should be performed both in dry and hydrated states for comparative purposes. 55 If the lens is delivered in a dry state, it should be rehydrated in balanced salt solution for 24 hours at room temperature for evaluation in a hydrated state. 55 However, for transportation, the IOL is usually placed in balanced salt solution or distilled water.…”

Section: Methods For Iol Evaluationmentioning

confidence: 99%

Microscopic Characteristics of Late Intraocular Lens Opacifications

Kanclerz¹,

Yildirim

Khoramnia

2020

Archives of Pathology &Amp; Laboratory Medicine

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Context.— The increases in overall life expectancy and in lens surgeries performed on younger patients have resulted in a significant increase in the anticipated duration of artificial intraocular lenses (IOLs) in the eye. Thus, the physicochemical properties of the IOL become a critical issue, and several types of postoperative IOL opacifications have been reported. Objective.— To describe the microscopic characteristics of opacified IOLs. Glistenings and subsurface nanoglistenings are fluid-related phenomena developing mainly in hydrophobic acrylic IOLs and are associated with aqueous influx into the IOL matrix. Calcification presents in hydrophilic acrylic or silicone IOLs as deposits of hydroxyapatite or other phases of calcium. Snowflake degeneration is less common, and it manifests in older polymethyl methacrylate IOLs. Data Sources.— PubMed and ScienceDirect databases were searched for the following keywords: intraocular lens, IOL, cataract surgery, phacoemulsification, opacification, glistening, subsurface nanoglistenings, calcification, snowflake degeneration. English-language articles published up to October 15, 2019 were included in the study. The manuscript contains mainly a literature review; however, it was supplemented with original investigations from the David J. Apple International Laboratory for Ocular Pathology Conclusions.— Glistenings and subsurface nanoglistenings should be evaluated in hydrated state and at room temperature; they manifest as microvacuoles sized from 1.0 to greater than 25.0 μm and less than 200 nm, respectively. Calcification deposits are situated on or underneath the surface of the IOL and can be stained with a 1% alizarin red solution or with the von Kossa method. Snowflake degeneration manifests as “particles” or “crystals,” causing whitish IOL discoloration. Scanning electron microscopy or energy dispersive X-ray spectroscopy may improve the diagnostic accuracy.

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“…Indeed, this occurred in the study by Michelson et al 1 in which a decrease in transmission was found when the IOLs, which had been explanted because of opacification, were analyzed using a spectrophotometer with an integrating sphere. On the contrary, as we pointed out above, Werner et al 5 found variation in the scattering, but not in the transmittance, when they studied surface light scattering in IOLs removed from cadaver eyes.…”

Section: Introductionmentioning

confidence: 65%

“…2 Glistenings are fluid-filled microvacuoles that form inside the intraocular lens optic when the IOL is in an aqueous environment, thereby producing an internal light scattering which is difficult to distinguish from surface light scattering. [2][3][4] Werner et al, 5 when analyzing some one-piece hydrophobic acrylic IOLs removed from cadaver eyes, demonstrated that surface light scattering significantly increased when compared with scattering in IOLs that had not been used, but their transmittance did not vary. Although the controversy continues, it seems that the cause of light scattering on the surface of hydrophobic acrylic IOLs (referred to by some authors as whitening) is due to a trace of water molecules that infiltrate the optic.…”

Section: Introductionmentioning

confidence: 99%

Determination of scattering in intraocular lenses by spectrophotometric measurements

et al. 2014

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Abstract. This study presents a method for measuring scattering in explanted intraocular lenses (IOLs). Currently, determining scattering in IOLs is usually performed by Scheimpflug cameras and the results are expressed in the units used by this apparatus. The method we propose uses a spectrophotometer and this makes it possible to measure the total transmission of the IOL by using an integrating sphere; the direct transmission is determined by the double-beam mode. The difference between these two transmissions gives a value of the scattering in percentage values of light lost. In addition, by obtaining the spectral transmission curve, information about the most scattered wavelengths is also obtained. The IOL power introduces errors when directly measured, particularly with high powers. This problem can be overcome if a tailor-made cuvette is used that shortens the distance between the IOL and the condensing lens of the spectrophotometer when the IOL powers are below 24 diopters. We checked the effectiveness of this method by measuring the scattering of three explanted IOLs from cornea donors. This method, however, does not make it possible to ascertain whether the scattering measured is caused by surface light scattering or internal light scattering. © The Authors.Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Light transmittance of 1-piece hydrophobic acrylic intraocular lenses with surface light scattering removed from cadaver eyes

Abstract: Although surface light scattering of explanted IOLs was significantly higher than that of controls and appeared to increase with time, no effect was observed on light transmittance of 1-piece hydrophobic acrylic IOLs with or without a blue-light filter.

Cited by 16 publications

References 15 publications

Decreased visual acuity resulting from glistening and sub-surface nano-glistening formation in intraocular lenses: A retrospective analysis of 5 cases

Decreased visual acuity resulting from glistening and sub-surface nano-glistening formation in intraocular lenses: A retrospective analysis of 5 cases

Microscopic Characteristics of Late Intraocular Lens Opacifications

Determination of scattering in intraocular lenses by spectrophotometric measurements

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