Light treatment prevents fatigue in women undergoing chemotherapy for breast cancer

Ancoli‐Israel, Sonia; Rissling, Michelle; Neikrug, Ariel B.; Trofimenko, Vera; Natarajan, Loki; Parker, Barbara A.; Lawton, Susan; Desan, Paul H.; Liu, Lianqi

doi:10.1007/s00520-011-1203-z

Cited by 98 publications

(77 citation statements)

References 35 publications

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“…[76] This area of research could be advanced by including selected cognitive measures concurrently with fatigue and energy state measures. [77] A final concern is that several potential moderators could not be considered, including biological sex, [78] variations in exposure to bright light resulting from indoor versus outdoor exercise, [79] and variations in sleepiness resulting from the prior night's sleep or daytime naps. [80] Understanding the effect of acute exercise on energy and fatigue is also limited in part because of inadequate reporting of physical activity history as well as the dimensions of the acute exercise stimulus (intensity, duration, mode).…”

Section: Fatigue Moderatorsmentioning

confidence: 99%

The effect of a single bout of exercise on energy and fatigue states: a systematic review and meta-analysis

Loy

O’Connor

Dishman

2013

Fatigue: Biomedicine, Health & Behavior

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Background: Studies examining acute exercise effects on energy and fatigue levels have not been quantitatively summarized. Purpose: To estimate the population effects of a single bout of exercise on energy and fatigue states and examine potential moderators. Methods: Google Scholar and MEDLINE were searched systematically for published studies that measured changes in energy and fatigue after acute exercise. Meta-analytic techniques were used to analyze 58 energy effects and 58 fatigue effects from the same 16 studies involving 678 participants. Most studies involved 21-40 minutes of moderate-intensity aerobictype exercise. Result: The homogeneous mean effect for energy was Δ = 0.47 (95% confidence interval [CI] = 0.39, 0.56). The heterogeneous mean effect for fatigue was Δ = 0.03 (95% CI = −0.08, 0.13). The fatigue effect was moderated by a three-way interaction between change in feelings of energy, exercise intensity, and exercise duration. Conclusion: Acute exercise enhances feelings of energy. Decreases in fatigue occur only when post-exercise increases in energy are at least moderately large after low-to-moderate intensity exercise lasting longer than 20 minutes. Future research should focus on short-duration (<15 minutes), vigorous-intensity exercise and long-duration (>40 minutes) exercise in non-student groups.

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Section: Fatigue Moderatorsmentioning

confidence: 99%

The effect of a single bout of exercise on energy and fatigue states: a systematic review and meta-analysis

Loy

O’Connor

Dishman

2013

Fatigue: Biomedicine, Health & Behavior

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“…11 Indeed, sLE using bright light has been shown to improve sleep quality in noncancer populations 12 and has improved correlates of sleep disturbance in cancer patients, including circadian activity rhythms 13 and fatigue, both during chemotherapy 14 and, in our current sample, after primary cancer treatment for fatigue.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Systematic Light Exposure on Sleep in a Mixed Group of Fatigued Cancer Survivors

Amidi

Valdimarsdottir

et al. 2018

Journal of Clinical Sleep Medicine

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Study Objectives: Sleep disturbances are commonly reported by cancer survivors. Systematic light exposure using bright light has been used to improve sleep in other populations. In this secondary data analysis, the effect of morning administration of bright light on sleep and sleep quality was examined in a mixed group of fatigued cancer survivors. Methods: Forty-four cancer survivors screened for cancer-related fatigue were randomized to either a bright white light or a comparison dim red light condition. Participants were instructed to use a light box every morning for 30 minutes for 4 weeks. Wrist actigraphy and the Pittsburgh Sleep Quality Index were administered at 4 time points: prior to light treatment (baseline), 2 weeks into the intervention, during the last week of the intervention, and 3 weeks postintervention. Thirty-seven participants completed the end-of-intervention assessment. Results: Repeated-measures linear mixed models indicated a statistically significant time × treatment group interaction effect with sleep efficiency improving more in the bright light condition over time compared with the dim light condition (F3,42 = 5.55; P = .003) with a large effect size (partial η 2 = 0.28). By the end of the intervention and 3 weeks postintervention, mean sleep efficiency in the bright light group was in the normal range. Medium to large effect sizes were also seen in sleep quality, total sleep time, and wake after sleep onset for participants favoring the bright light condition. Conclusions:The results suggest that systematic bright light exposure in the morning may have beneficial effects on sleep in fatigued cancer survivors. Larger scale efficacy trials are warranted.

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“…170,178,182 Chronobiotics such as bright light, physical and social activity, meal timing, and sleep patterns could further strengthen or resynchronize the circadian timing system 183,184 and help to improve anticancer therapy outcome.…”

Section: Resultsmentioning

confidence: 99%

Circadian rhythms and new options for novel anticancer therapies

Zmrzljak¹

2015

CPT

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The patterns of activity/sleep, eating/fasting, etc show that our lives are under the control of an internal clock. Cancer is a systemic disease that affects sleep, feeding, and metabolism. All these processes are regulated by the circadian clock on the one hand, but on the other hand, they can serve as signals to tighten up the patient's circadian clock by robust daily routine. Usually, anticancer treatments take place in hospitals, where the patient's daily rest/activity pattern is changed. However, it has been shown that oncology patients with a disturbed circadian clock have poorer survival outcomes. The administration of different anticancer therapies can disturb the circadian cycle, but many cases show that circadian rhythms in tumors are deregulated per se. This fact can be used to plan anticancer therapies in such a manner that they will be most effective in antitumor action, but least toxic for the surrounding healthy tissue. Metabolic processes are highly regulated to prevent waste of energy and to ensure sufficient detoxification; as a consequence, xenobiotic metabolism is under tight circadian control. This gives the rationale for planning the administration of anticancer therapies in a chronomodulated manner. We review some of the potentially useful clinical praxes of anticancer therapies and discuss different possible approaches to be used in drug development and design in the future.

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Light treatment prevents fatigue in women undergoing chemotherapy for breast cancer

Cited by 98 publications

References 35 publications

The effect of a single bout of exercise on energy and fatigue states: a systematic review and meta-analysis

The effect of a single bout of exercise on energy and fatigue states: a systematic review and meta-analysis

The Effect of Systematic Light Exposure on Sleep in a Mixed Group of Fatigued Cancer Survivors

Circadian rhythms and new options for novel anticancer therapies

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