Light-Triggered Adhesive Silk-Based Film for Effective Photodynamic Antibacterial Therapy and Rapid Hemostasis

Abstract

Successful control of massive hemorrhage in deep wounds with irregular shape and low elasticity still remains great challenges in the clinic. As the wound sites are usually at risk of bacterial infection, it is necessary to design an ideal hemostatic agent with rapid hemostasis and excellent antibacterial activity. In this study, we developed a light responsive hemostatic film for effective handling of liver bleeding with promising photodynamic therapy against S. aureus onnear infrared (NIR) irradiation. Based on silk fibroin, the film exhibited desirable biocompatibility and mechanical property as a hemostat tape. Significantly, the film tape achieved excellent tissue adhesion and hemostasis in vivo within 2 min of UV exposure, which would have a great potential as a multifunctional biomedical material in the field of tissue repair such as wound healing, bone repair, and nerve regeneration.

Silk Fibroin-Based Biomaterials for Hemostatic Applications

“…SF films have been vastly applied for wound dressing materials in numerous studies. Recently, Huang et al reported a light-triggered SF-based film with effective antibacterial activity for hemostatic applications [74]. In this study, they developed a light-responsive SF film to effectively manage liver hemorrhage with effective treatment against S. aureus SF films are a candid biomaterial of choice for biomedical applications owing to their intrinsically less complex character regarding scaffold development.…”

“…Recently, Huang et al reported a light-triggered SF-based film with effective antibacterial activity for hemostatic applications [74]. In this study, they developed a light-responsive SF film to effectively manage liver hemorrhage with effective treatment against S. aureus on near-infrared (NIR) irradiation.…”

Montmorillonite/Agarose Three-Dimensional Network Gel Sponge for Wound Healing with Hemostatic and Durable Antibacterial Properties

“…The wound-healing process proceeds in four phases: hemostasis, inflammation, proliferation, and remodeling . Among these, uncontrollable bleeding and bacterial infection are the main challenges in the early stages of wound healing. , To stop bleeding quickly and prevent infection, wounds are often treated clinically with hemostatic materials and antibiotic drugs. , Currently, there are many clinically available hemostatic materials, such as conventional wound dressing, , microporous aluminosilicates (zeolites and clays), , or various polymer-based materials (e.g., hydrogels, sponges, and films). − Although all of them have hemostatic functions, they still have some disadvantages. For example, conventional wound dressings are usually less effective and need long-term treatment .…”

Development of ε-poly(L-lysine) carbon dots-modified magnetic nanoparticles and their applications as novel antibacterial agents

“…In recent years, nanomaterials have gradually attracted great interest due to their unique characteristics, including small size, easy modification, and high reactivity (Biju, 2014;Zhou et al, 2018b;Wu et al, 2020;Tang et al, 2021;Zheng et al, 2021). Particularly, they have been widely applied in biomedical fields, such as tissue engineering, bioimaging, cancer therapy, and antibacterial applications (Ku et al, 2013;Zhou et al, 2016;Liguori et al, 2019;Tang X. et al, 2020;Makabenta et al, 2021;Wang et al, 2021;Huang et al, 2022;Song et al, 2022). Among various nanomaterials, magnetic nanoparticles (MNPs), which have been approved by the U.S. Food and Drug Administration (FDA), received considerable attention for their broad biomedical applications (e.g., magnetic resonance imagining, diagnostics, drug delivery, hyperthermia, etc.)…”