Light‐Triggered Assembly of Gold Nanoparticles for Photothermal Therapy and Photoacoustic Imaging of Tumors In Vivo

Cheng, Xiaju; Sun, Rui; Yin, Ling; Chai, Zhifang; Shi, Haibin; Gao, Mingyuan

doi:10.1002/adma.201604894

Cited by 495 publications

(341 citation statements)

References 45 publications

Supporting

Mentioning

339

Contrasting

Order By: Relevance

“…Additionally, spherical AuNMs need to be more than 50 nm in size to effectively absorb in the NIR region. To overcome this size limitation, spherical AuNMs decorated with photolabile diazirine moieties, have been developed as PTT agents [115]. When exposed to UV irradiation, the diazirine moieties caused the AuNMs to aggregate in the tumor site, changing their size and resulting in a significant shift in their LSPR peak towards the NIR region, which in consequence induced plasmonic coupling between adjacent AuNMs and remarkably enhanced their efficacy for PTT.…”

Section: Photothermal Therapy (Ptt)mentioning

confidence: 99%

Latest advances in combining gold nanomaterials with physical stimuli towards new responsive therapeutic and diagnostic strategies

Movia

Benhaddada

Spadavecchia

et al. 2020

Precision Nanomedicine

View full text Add to dashboard Cite

Graphical abstract KeywordsGold nanoparticle 1 ; external stimuli; physical stimuli; physically triggered nanomedicine. Quote this article as: Movia D, Benhaddada M, Jolanda Spadavecchia J, Prina-Mello A, Latest advances in combining gold nanomaterials with physical stimuli towards new responsive therapeutic and diagnostic strategies, Precis. Nanomed. 2020 April;3(2):495-524, https://doi. AbstractNanomedicine aims at enhancing treatment efficiency and/or improving diagnostic sensitivity by better controlling several critical parameters, such as tissue targeting and off-target toxicity. More recently, advanced nanomedicine products have been developed to achieve spatially and temporally controlled therapy and diagnosis. This review focuses on gold nanomaterials (AuNMs) and alloy/hybrid AuNMs that can be used in stimuli-responsive strategies for therapeutic and diagnostic applications. Endogenous and/or exogenous stimuli can be used as a trigger for such systems. Herein, we focus on those activated by exogenous stimuli. Our review starts from one specific externally activated product, Aurolase®, which recently underwent clinical studies. Further we continue describing a specific physically triggered category, for which the exogeneous stimulus applied induces a structural transformation or modification that is essential for their therapeutic and/or diagnostic action. Gold nanomaterials are grouped both by the nature of the function they exert (therapeutic or diagnostic) and the stimuli class.

show abstract

Section: Photothermal Therapy (Ptt)mentioning

confidence: 99%

Latest advances in combining gold nanomaterials with physical stimuli towards new responsive therapeutic and diagnostic strategies

Movia

Benhaddada

Spadavecchia

et al. 2020

Precision Nanomedicine

View full text Add to dashboard Cite

show abstract

“…Some inorganic/organic hybrid nanomaterials have high absorption in the NIR region and could be served as contrast agents for PAI . To achieve the PAD selectivity of analytes, responsive molecules are blended into hybrid nanomaterials.…”

Section: Construction Of Pa Probes In Padmentioning

confidence: 99%

“…Some inorganic/organic hybrid nanomaterials have high absorption in the NIR region and could be served as contrast agents for PAI. [20] To achieve the PAD selectivity of analytes, responsive molecules are blended into hybrid nanomaterials. In general, these hybrid nanomaterial-based responsive PA probes usually contain two components: 1) PA contrast agents and 2) responsive molecules with the reaction or recognition groups (antibodies, polypeptides, enzyme substrates, and so on).…”

Section: Hybrid Nanomaterialsmentioning

confidence: 99%

Photoacoustic Probes for Molecular Detection: Recent Advances and Perspectives

Zeng

Lin

et al. 2018

Small

View full text Add to dashboard Cite

Photoacoustic (PA) imaging (PAI) is a noninvasive and nonionizing biomedical imaging modality that combines the advantages of optical imaging and ultrasound imaging. Based on PAI, photoacoustic detection (PAD) is an emerging approach that is involved with the interaction between PA probes and analytes resulting in the changes of photoacoustic signals for molecular detection with rich contrast, high resolution, and deep tissue penetration. This Review focuses on the recent development of PA probes in PAD. The following contents will be discussed in detail: 1) the construction of PA probes; 2) the applications and mechanisms of PAD to different types of analytes, including microenvironments, small biomolecules, or metal ions; 3) the challenges and perspectives of PA probes in PAD.

show abstract

“…Self‐assembly of plasmonic nanocrystals (PNCs) can control metal–light interaction via confined electromagnetic fields arising from excited localized surface plasmon resonance (LSPR), which is of considerable interest for a variety of applications, including surface‐enhanced Raman scattering (SERS), metal‐enhanced fluorescence (MEF), photothermal therapy (PTT), photoacoustic imaging (PAI), photodynamic therapy (PDT), photocatalysis, and plasmon‐assisted lithography . The LSPR of PNCs can be tailored and amplified by engineering their surface chemistry, dimension, and geometry .…”

Section: Introductionmentioning

confidence: 99%

Self‐Assembly of Polymer‐Coated Plasmonic Nanocrystals: From Synthetic Approaches to Practical Applications

Zhou

Chen

et al. 2018

Macromol. Rapid Commun.

View full text Add to dashboard Cite

Such coupling can induce significant red-shifts in LSPR spectra and create greatly enhanced electromagnetic fields, both of which endow plasmonic assemblies with dramatically different optical properties compared to single PNC counterparts. [43,[48][49][50] Small molecular surfactants (i.e., hexadecyltrimethylammonium bromide-CTAB), [51] silica, [52][53][54] biomacromolecules (e.g., DNA), [55][56][57][58][59] and synthetic polymers are the most commonly used surface coatings for PNCs, [60,61] imparting surface functionalities to direct their selfassembly. Small molecular surfactants are able to provide decent stability in dielectric environments (e.g., aqueous solution), although their relatively small sizes makes it difficult to control interparticle spacing or intraparticle gap sizes. Both silica and DNA have been used as "spacers" for the SERS and fluorescence signal enhancement, but inherent size limits hold back their further extended uses. For example, the silica coating is difficult for building a gap of smaller than 10 nm, [52,62] while DNA has not demonstrated its utility in realizing a relatively large nanogap (i.e., >2 nm). [57,59] Consequently, such size-tuning limitation makes them challenging to offer sufficient structural flexibility to tailor the LSPR, which is crucial for obtaining an optimal enhancement effect (e.g., fluorescence enhancement). [52,63,64] Moreover, the coassembly of DNA and PNC is primarily based on the base-pairing recognition, [58,65,66] which is too specific for the extensive uses.In contrast, there are a number of benefits in conjugating polymers with PNCs to direct their self-assembly: i) The conformation transformation of polymer chains provides the driving force for self-assembly. [43,45,48,[67][68][69] For example, the amphiphilic single-component or mixed polymer brushes anchored onto the PNCs can afford amphiphilicity-driven self-assembly to produce a library of assemblies including core-shell structure, Janus nanoparticles (JNPs), nanocluster, nanochain, lamellae, and vesicle. ii) The polymeric corona protects the PNC core and stabilizes the assemblies in dispersion media. [68,70,71] iii) By using stimuli-responsive polymer coatings, the formed assemblies can readily undergo structural changes in response to the external triggers. [15,[72][73][74][75][76] Moreover, the strength of interactions between polymer/PNC hybrid materials and external stimuli can be adjusted by varying the structures of the polymer coating, such as molecular weight (M w ) of the polymer. The large-sized polymer coating leads to more significant multivalent effects compared to small molecular ligands. iv) Also important is Plasmonic Nanocrystals Self-assembly of plasmonic nanocrystals (PNCs) and polymers provides access to a variety of functionalized metallic-polymer building blocks and higher-order hybrid plasmonic assemblies, and thus is of considerable fundamental and practical interest. The hybrid assemblies often not only inherit individual characteristics of polymers and PNCs but also exhi...

show abstract

Light‐Triggered Assembly of Gold Nanoparticles for Photothermal Therapy and Photoacoustic Imaging of Tumors In Vivo

Cited by 495 publications

References 45 publications

Latest advances in combining gold nanomaterials with physical stimuli towards new responsive therapeutic and diagnostic strategies

Latest advances in combining gold nanomaterials with physical stimuli towards new responsive therapeutic and diagnostic strategies

Photoacoustic Probes for Molecular Detection: Recent Advances and Perspectives

Self‐Assembly of Polymer‐Coated Plasmonic Nanocrystals: From Synthetic Approaches to Practical Applications

Contact Info

Product

Resources

About