Light‐Triggered Nitric Oxide Nanogenerator with Highl‐Arginine Loading for Synergistic Photodynamic/Gas/Photothermal Therapy

Abstract

The development of nanomedicines that combine photothermal therapy (PTT) with photodynamic therapy (PDT) is considered promising for cancer treatment, but still faces the challenge of enhancing tumoricidal efficiency. Fortunately, apart from the well‐acknowledged effect on direct tumor cell‐killing, nitric oxide (NO) is also considered to be effective for the enhancement of both PTT and PDT. However, both the low loading efficiency of NO precursor and the short half‐life time and diffusion distance of NO hamper the synergistic therapeutic efficacy of NO. Taking the aforementioned factors into account, a mitochondria‐targeted nitric oxide nanogenerator, EArgFe@Ce6, is constructed to achieve high loading of the NO donor l‐Arginine (l‐Arg) for synergistic photodynamic/gas/photothermal therapy upon single 660 nm light irradiation. The coordination of epigallocatechin gallate (EGCG) and ferric ions (Fe3+) provides EArgFe@Ce6 supreme photothermal capability to perform low‐temperature PTT (mPTT). EGCG endows EArgFe@Ce6 with mitochondria‐targeting capability and meanwhile favors hypoxia alleviation for enhanced PDT. The PDT‐produced massive reactive oxygen species (ROS) further catalyzes l‐Arg to generate a considerable amount of NO to perform gas therapy and sensitize both mPTT and PDT. In vitro and in vivo studies demonstrate that the synergistic photodynamic/gas/photothermal therapy triggered by single 660 nm light irradiation is highly effective for tumor treatments.

Ionic Functionalized Magnetic Porous Polymers as Advanced Materials for High-Efficiency Water Decontamination: Bactericidal and Iodine Adsorption

“…To demonstrate the excellent photothermal properties of FP-POP and iFP-POP, the laser-induced temperature change trends under 638 nm laser irradiation were finely examined by adjusting either the concentration of the polymers (25–400 μg mL –1 ) or the laser power density (0.5–2.0 W cm –2 ). As displayed in Figure a,b, both polymers showed concentration-dependent warming behaviors . After 15 min of laser irradiation (638 nm, 1.5 W cm –2 ), the temperatures of FP-POP and iFP-POP were gradually increased from 30.9 to 68.9 °C and from 32.4 to 74.2 °C, respectively, with a concentration variation from 25 to 400 μg mL –1 .…”

“…As displayed in Figure 3a,b, both polymers showed concentration-dependent warming behaviors. 46 After 15 min of laser irradiation (638 nm, 1.5 W cm −2 ), the temperatures of FP-POP and iFP-POP were gradually increased from 30.9 to 68.9 °C and from 32.4 to 74.2 °C, respectively, with a concentration variation from 25 to 400 μg mL −1 . Even at a low concentration of 200 μg mL −1 , the temperatures of FP-POP and iFP-POP also increased to 57 and 58.1 °C, respectively.…”

Lysosome-targeted silicon quantum dots theranostics for simultaneous fluorescent imaging and photodynamic therapy

“…In order to verify the biological safety of L-Si QDs and the phototoxicity of L-Si QDs to kill cancer cells, the dark toxicity of L-Si QDs to normal cells and phototoxicity to tumor cells were tested by MTT assay [68]. The MTT results of L-Si QDs on HU-EVC normal tissue cells in figure 6(a) showed that L-Si QDs had excellent biological safety.…”

Multi-Enzyme Cascade-Triggered Nitric Oxide Release Nanoplatform Combined with Chemo Starvation-like Therapy for Multidrug-Resistant Cancers

“…The former could be used for gas therapy, and the latter provided CDT and could be used as a contrast agent for T1-weighted MRI . Similarly, NO enrichment leads to cellular DNA damage while enhancing PDT by inhibiting tumor cell respiration and oxygen consumption . Gox and l -arg have also been coadministered to produce NO for gas/starvation therapy of tumors by consuming glucose .…”