“…We identified 49 randomized controlled trials, 41 from personal file, MEDLINE, and EMBASE searches, 7 more from hand searching anesthesia journals, and 1 from an expert in the field. Of the 49 trials, 17 were excluded [52][53][54][55][56][57][58][59][60][61][62][63][64][65][66][67][68] (4 addressed a different population [52][53][54][55][56] [2 normal volunteers, 1 nonventilated ICU patients, 1 intraoperative cardiac surgery anesthesia patients], 2 evaluated different outcomes 57,58 [renal function of isoflurane, urine, and plasma catecholamines], and 6 investigated dif-ferent dosing schedules or modes of administering a single agent [59][60][61][62][63][64][65][66][67][68] ), leaving 32 trials for analysis.…”