COVID-19 is a pandemic with a wide reach and explosive magnitude, and the world has been bracing itself for impact. Many have lost their jobs and savings, and many are homeless. For better or worse, COVID-19 has permanently changed our lives. For college students, the pandemic means giving up most of the on-campus experience in the postpandemic era and performing online learning instead. Virtual lessons may become a permanent part of college education. Large-scale online learning typically utilizes interactive live video streaming. In this study, we analyzed a codec and video streaming transmission protocol using artificial intelligence. First, we studied an intraframe prediction optimization algorithm for the H.266 codec based on long short-term memory networks. In terms of video streaming transmission protocols, real-time communication optimization based on Quick UDP Internet connections and Luby Transform codes is proposed to improve the quality of interactive live video streaming. Experimental results demonstrate that the proposed strategy outperforms three benchmarks in terms of video streaming quality, video streaming latency, and average throughput.