Topology optimization and lattice design strategies are excellent tools within the design for additive manufacturing (DfAM) workflow as they generate structurally optimal, lightweight, and complex features often difficult to produce by conventional manufacturing methods. Moreover, topology optimization approaches are quickly evolving to accommodate AM-related processes and geometric constraints. In this study, the re-design of the connecting rod of an internal combustion engine (ICE) is explored by topology optimization and lattice structures. In both topology optimization and lattice design, the objective is to maximize their structural performances while constraining material usage. Structural analyses are carried out on the optimized topologies to compare their mechanical performances with a benchmark design. Results show that the redesign of the connecting rod through topology optimization alone can realize 20% material savings with only a 5% reduction in the factor of safety. However, the combination of topology optimization and lattice structure design can result in over 50% material savings with a 21–26% reduction in the factor of safety. For manufacturability, the fast-predictive inherent strain model shows the designs through topology optimization and lattice design gives the lowest process-induced deformations before and after support structure removal.