Lighting up Carbon Monoxide: Fluorescent Probes for Monitoring CO in Living Cells

Yuan, Lin; Lin, Weiying; Tan, Li; Zheng, Kaibo; Huang, Wei Min

doi:10.1002/anie.201208346

Cited by 99 publications

(67 citation statements)

References 25 publications

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“…24 The COP-1 probe displays a larger fluorescence signal enhancement (10-fold) than the genetically encoded fluorescent probe COSer (2-fold) in vitro . However, the biosensor COSer is faster than COP-1 in the response time.…”

Section: Co Detectionmentioning

confidence: 99%

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Carbon monoxide – physiology, detection and controlled release

et al. 2014

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Carbon monoxide (CO) is increasingly recognized as a cell-signalling molecule akin to nitric oxide (NO). CO has attracted particular attention as a potential therapeutic agent because of its reported anti-hypertensive, anti-inflammatory and cell-protective effects. We discuss recent progress in identifying new effector systems and elucidating the mechanisms of action of CO on, e.g., ion channels, as well as the design of novel methods to monitor CO in cellular environments. We also report on recent developments in the area of CO-releasing molecules (CORMs) and materials for controlled CO application. Novel triggers for CO release, metal carbonyls and degradation mechanisms of CORMs, are highlighted. In addition, potential formulations of CORMs for targeted CO release are discussed.

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Section: Co Detectionmentioning

confidence: 99%

“…24 In addition, emerging concepts on the anti-inflammatory actions of CORMs have been shown. 3,12 A perspective on CORMs was written by Mann.…”

Section: A Introductionmentioning

confidence: 99%

Carbon monoxide – physiology, detection and controlled release

et al. 2014

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“…An important tool in facilitating this localization is the use of multi-functional photoCORMs that provide an identifier tag that can be combined with imaging techniques to identify the fate and localization of both the photoCORMs and the iCORMs within biological systems. Being able to directly identify the photoCORM makes this type of proposed therapy more powerful because identifying CO in vivo is significantly more difficult by comparison, although there have been some recent developments in this regard [142][143][144].…”

Section: Challenges Associated With Designing Photocormsmentioning

confidence: 99%

Photo-Controlled Release of NO and CO with Inorganic and Organometallic Complexes

Pierri

Muizzi

Ostrowski

et al. 2014

Luminescent and Photoactive Transition Metal Complexes as Biomolecular Probes and Cellular Reagents

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Abstract:The photochemical delivery of bioactive small molecules to physiological targets provides the opportunity to control the location, timing and dosage of such delivery. We will discuss recent developments the synthesis and studies of various metal complexes designed for targeted release of the bioregulatory diatomics nitric oxide and carbon monoxide. Of considerable interest are those systems where the NO or CO precursor and/or the photochemical product is luminescent such that imaging techniques allow one to identify the release location.

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“…The major obstacle in this area is the lack of real-time approaches to selectively track CO in biological systems. Some established approaches for CO detection include gas chromatography, chromogenic detection, laser sensor-infrared absorption, electrochemical assays, etc, [5][6][7][8] [15][16][17][18][19][20] including our newly reported probe. 21 However, almost all of these probes display emissions in the visible region, which greatly restricts their applications in biological imaging, due to the strong autofluorescence and limited tissue penetration.…”

Section: Introductionmentioning

confidence: 99%