The cross-section, thickness, and material of the autobody structure determine the crashworthiness and lightweight level. Different from the variables in traditional autobody design that are considered separately, the basic theory of 3G-optimization is to simultaneously consider geometric shape (Geometry), the thickness of structure (Gauge), and material grade (Grade) in structural optimization design, which is conducive to maximizing the lightweight potential of the structure. This paper presents a cross-section optimization method for multi-cell thin-walled structures based on 3G-optimization, which is used in the structural design of crash box. Based on full width frontal collision condition, the cross-section shape, thickness, and material variables of the multi-cell crash box are optimized simultaneously. Multiple sets of optimization schemes show obvious weight reduction effect while ensuring safety. Besides, the sub-system decoupling method and hybrid cellular automaton (HCA) method are applied to 3G-optimization process, which is beneficial to improve the calculation efficiency and provide a theoretical basis for the definition of the initial design space for 3G-optimization.