The idea of hydrogen-powered airplanes has recently attracted a revitalized push in the aviation sector to combat CO2 emissions. However, to also reduce, or even eliminate, non-CO2 emissions and contrails, the combination of hydrogen with all-electric solutions is undoubtedly the best option. This article explores the next wave of disruptive technological developments needed to scale up zero-emission aviation beyond 2035. With respect to conventional electrical propulsion, major breakthroughs will be needed in terms of reducing the voltage level while increasing system-level power density and overall efficiency. We show how a next-generation hydrogen-powered aircraft could take advantage of its onboard cryogenic fuels to cool the electrical components, enabling a cryo-electric superconducting drivetrain that could lead to extraordinary performances.