Lignan Glycosides and Flavonoid Glycosides from the Aerial Portion of Lespedeza cuneata and Their Biological Evaluations

Baek, Jin Wook; Lee, Tae Kyoung; Song, Jae-Hyoung; Choi, Eun Ae; Ko, Hyun‐Jeong; Lee, Sang‐Hyun; Choi, Sang Un; Lee, Seong; Yoo, Sang-Woo; Kim, Seung‐Chul; Kim, Ki‐Hyun

doi:10.3390/molecules23081920

Cited by 15 publications

(11 citation statements)

References 37 publications

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“…Of the 3 recent studies that investigated the anticancer activity of glycosides, one found no significant activity for two glycosides (Shan et al, 2018) and one found moderate anticancer activity for four glycosides (Baek et al, 2018). found relatively strong activity against breast cancer cell lines for cyanidin-3-glucoside isolated from Morus alba (mulberry).…”

Section: Anticancer Activitymentioning

confidence: 99%

Hitting the sweet spot: A systematic review of the bioactivity and health benefits of phenolic glycosides from medicinally used plants

Johnson

Mani

Broszczak

et al. 2021

Phytotherapy Research

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Phenolic acid and flavonoid glycosides form a varied class of naturally occurring compounds, characterised by high polarity-resulting from the glycone moiety-and the presence of multiple phenol functionalities, which often leads to strong antioxidant activity.Phenolic glycosides, and in particular flavonoid glycosides, may possess strong bioactive properties with broad spectrum activity. This systematic literature review provides a detailed overview of 28 studies examining the biological activity of phenolic and flavonoid glycosides from plant sources, highlighting the potential of these compounds as therapeutic agents. The activity of glycosides depends upon the biological activity type, identity of the aglycone and the identity and specific location of the glycone moiety. From studies reporting the activity of both glycosides and their respective aglycones, phenolic glycosides appear to generally be a storage/reserve pool of precursors of more bioactive compounds. The glycosylated compounds are likely to be more bioavailable compared to their aglycone forms, due to the presence of the sugar moieties. Hydrolysis of the glycoside in the in vivo environment would release the free aglycone, potentiating their biological activity. However, further high-quality studies are needed to firmly establish the clinical efficacy of glycosides from many of the plant species studied.

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Section: Anticancer Activitymentioning

confidence: 99%

Hitting the sweet spot: A systematic review of the bioactivity and health benefits of phenolic glycosides from medicinally used plants

Johnson

Mani

Broszczak

et al. 2021

Phytotherapy Research

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“…The compounds from the polar fractions were isolated and identified as avicularin and isovitexin ( Fig. 1) [18].…”

Section: Collection Of Plant Materials and Preparation Of Solvent Framentioning

confidence: 99%

Anti-oxidant activity of avicularin and isovitexin from Lespedeza cuneata

Lee

Quilantang

et al. 2019

JABC

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This study evaluated the anti-oxidant activity of avicularin and isovitexin from Lespedeza cuneata using 2,2-diphenyl-1picrylhydrazyl (DPPH) and hydroxyl (OH) scavenging assays. The results showed that among the four fractions, the highest OH radical scavenging activity was exhibited by the n-butanol fraction. The DPPH radical scavenging activities of avicularin and isovitexin were higher than 50% at a concentration of 100 μg/mL. Moreover, one hundred micrograms per liter of avicularin and isovitexin exhibited effective anti-oxidant activity, with the OH radical scavenging rates being 87.54 and 91.48%, respectively. These results suggest that Lespedeza cuneata would be useful anti-oxidant agents from natural sources.

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“…Phytochemical investigations of LC led to the isolation of tannins, β-sitosterol, pinitol, flavonoids, lignans and their glycosides. The flavonoids include vitexin, myricitrin, rutin, C-glycosyl flavones such as isovitexin, vicenin II, isoorientin, desmodin, lucenin II, and homoadonivernith, and O-glycosyl flavonols such as trifolin, hyperin, avicularin, juglanin, and hirsutrin [4,5].…”

Section: Introductionmentioning

confidence: 99%

Determination of isovitexin from Lespedeza cuneata using a validated HPLC-UV method

Lee

Paje

Yoo³

et al. 2021

JABC

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Isovitexin, a marker compound with various pharmacological activities, in Lespedeza cuneata, was analyzed using high performance liquid chromatography coupled with UV (HPLC/UV). There are no previous reports on using L. cuneata as the source material for the quantification of isovitexin. In this study, we developed an optimized method using HPLC-UV analysis, which was validated using various parameters. Our method demonstrated high specificity, and good separation of the chromatographic peak was achieved. Parameters such as linearity (r 2 >0.9997), precision, and accuracy indicated that our proposed analytical method had good reliability and sensitivity. These results demonstrate the utility and convenience of our method for rapidly quantifying isovitexin in L. cuneata extracts.

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Lignan Glycosides and Flavonoid Glycosides from the Aerial Portion of Lespedeza cuneata and Their Biological Evaluations

Cited by 15 publications

References 37 publications

Hitting the sweet spot: A systematic review of the bioactivity and health benefits of phenolic glycosides from medicinally used plants

Hitting the sweet spot: A systematic review of the bioactivity and health benefits of phenolic glycosides from medicinally used plants

Anti-oxidant activity of avicularin and isovitexin from Lespedeza cuneata

Determination of isovitexin from Lespedeza cuneata using a validated HPLC-UV method

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