Lignan Glycosides from Urena lobata

Luo, Yuan; Su, Cong; Ding, Ning; Qi, Bowen; Jia, Fangfang; Xu, Xiping; Liu, Xiao; Wang, Juan; Wang, Xiaohui; Tu, Pengfei; Shi, She‐Po

doi:10.3390/molecules24152850

Cited by 5 publications

(4 citation statements)

References 25 publications

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“…The results of this investigation corroborated the numerous phytochemical investigations conducted on these plants 8,13,22,33,[35][36][37][38][39][40] . Phytochemicals provide medical benefits to human beings.…”

Section: Determination Of the Mineral Compositionsupporting

confidence: 85%

Evaluation of Phytochemical Constituents and Elemental Profiling of Selected Medicinal Plants in South-West, Nigeria

Usin,

Okon,

Daramola

et al. 2024

Asian J. Biol. Sci

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Background and Objective: Phytochemicals are responsible for the definite physiological effects exerted on the human body by various parts of the plant and it has been reported to play a major role in nutrition and control of diseases. This study aimed to comparatively investigate the phytochemical and elemental components of five medicinal plants commonly used in South-Western, Nigeria. Materials and Methods: Qualitative and quantitative phytochemical screening of all the extracts was done using different standard methods. Calcium, potassium, magnesium, phosphorus, iron and other elements were determined using standard procedures. Results: Preliminary qualitative phytochemical screening indicates the presence of glycosides, saponins, tannins, flavonoids, alkaloids and anthraquinones. The quantitative phytochemical screening revealed that glycosides, saponins, tannins, flavonoids, alkaloids and anthraquinones were significantly (p<0.05) higher in ethanol extract compared to ethyl acetate extract in all the studied medicinal plants, however, the reverse was the case in Urena lobata. Sodium (Na), potassium (K) and calcium (Ca) were significantly (p<0.05) higher in ethyl acetate extract than in ethanol extract in all the studied medicinal plants. While, iron (Fe), lead (Pb), cadmium (Cd) and arsenic (As) were significantly (p<0.05) higher in ethanol extract compared to ethyl acetate extract in all the studied medicinal plants. Conclusion: This study suggests the different range of phytochemicals present in the medicinal plants studied with their potential therapeutic benefits, emphasizing the significance of these plants in traditional and modern medicine. Furthermore, the elemental composition sheds light on the nutritional and essential value of these plants, which could contribute to their holistic healing properties.

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Section: Determination Of the Mineral Compositionsupporting

confidence: 85%

Evaluation of Phytochemical Constituents and Elemental Profiling of Selected Medicinal Plants in South-West, Nigeria

Usin,

Okon,

Daramola

et al. 2024

Asian J. Biol. Sci

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“…The molecular formula C 18 H 20 N 2 O 4 was established by HRESIMS at m/z 351.1413 [M + Na] + ( Figure S37 ) and 13 C NMR data ( Figure S31 ). The 1 H NMR data of 4 ( Table 2 ) indicated the presence of an ABX pattern [ δ H 7.43 (1H, d, J = 2.0 Hz, H-2), 6.83 (1H, d, J = 8.0 Hz, H-5), and 7.41 (1H, dd, J = 2.0, 8.0 Hz, H-6)] [ 21 ], a monosubstituted benzene moiety [ δ H 7.39 (2H, m, H-3′,5′) and 7.32 (3H, m, H-2′,4′,6′)], three methylene moieties [ δ H 4.52 (2H, s, H-13), 3.92 (2H, t, J = 8.0 Hz, H-9), and 3.55 (2H, t, J = 8.0 Hz, H-10)], and a methoxy group [ δ H 3.79 (3H, s, -OCH 3 )]. The 13 C NMR spectroscopic data ( Table 2 ) of 4 displayed resonance for 16 carbons, which was confirmed by the DEPT ( Figure S32 ) and HSQC ( Figure S34 ) experiments to be a·methoxy group [ δ C 55.5 (-OCH 3 )], 3 methylenes [ δ C 49.8 (C-9), 48.2 (C-13), and 31.1 (C-10)], 6 methines, and 6 quaternary carbons.…”

Section: Resultsmentioning

confidence: 99%

Four New Benzoylamide Derivatives Isolated from the Seeds of Lepidium apetalum Willd. and Ameliorated LPS-Induced NRK52e Cells via Nrf2/Keap1 Pathway

Zhang

Zeng

et al. 2022

Molecules

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Four new benzoylamide derivatives,lepidiumamide B–E (1–4), were isolated from the seeds of Lepidium apetalumWilld. The structures were determined by a combination of MS and NMR analyses. All compounds were evaluated for their protective effects against NRK-52e cell injury induced by lipopolysaccharide (LPS) in vitro. These compounds showed significantly protective activity and ameliorated LPS-induced NRK52e cells via the Nrf2/Keap1 pathway. The discovery of these active compounds is important for the prevention and treatment of renalinjury.

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“…Scientific reports indicate that the plant has anti-bacterial, antihyperglycemic, anti-nociceptive, anti-diarrheal, antiinflammatory, and wound healing activities [8,22,28]. A recent study suggests that compounds from U. lobata can inhibit nitric oxide production in lipopolysaccharide-induced RAW264.7 macrophage cells [20]. In China, U. lobata is clinically used to treat pathological leucorrhea and gonorrhea [23].…”

Section: Introductionmentioning

confidence: 99%

“…In China, U. lobata is clinically used to treat pathological leucorrhea and gonorrhea [23]. To date, a number of bioactive constituents have been isolated from this medicinal herb; these include flavonoids, phenylethyl glycosides, lignans, coumarins, triglycerides [14,20,25,35,37], megastigmane glycosides [36], urenalignosides A-D, and lignins [20].…”

Section: Introductionmentioning

confidence: 99%

Anxiolytic-like effect of Urena lobata (L.) in swiss albino mice

et al. 2021

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Anxiety disorders are general and psychological problems that are also linked to symptoms of depression. This study aimed to investigate the anxiolytic-like effects of Urena lobata L. (MEUL) methanolic extract in different behavioral paradigms in Swiss albino mice. For this, after an oral acute toxicity study, adult male mice were treated with MEUL (250 and 500 mg/kg, p.o.) and/or diazepam (2 mg/kg, i.p.), and subjected to a number of behavioral studies. In the open-field test, the number of square field cross, grooming, and rearing, was counted, while in the light/dark and swing test, the time spent in the dark portion and number of swings was calculated, respectively. Additionally, the phytochemical analysis was also done. Results reveal that the MEUL possesses alkaloids, glycosides, flavonoids, phenols, saponins, terpenes (including triterpenes), gums, and reducing sugars. MEUL showed a significant (p < 0.05) anxiolytic-like effect in experimental animals, where it’s dose-dependently modulated the test parameters in an open-field test. The MEUL also increased the light residence time and the number of swings in a dose-dependent manner. A dose of 500 mg/kg of MEUL caused the highest calming effect when combined with the experimental animals’ diazepam group. Taken together, findings expand an understanding of the impact of U. lobata on the central nervous system and show that this plant may be useful for the treatment of disorders associated with anxiety.

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Lignan Glycosides from Urena lobata

Cited by 5 publications

References 25 publications

Evaluation of Phytochemical Constituents and Elemental Profiling of Selected Medicinal Plants in South-West, Nigeria

Evaluation of Phytochemical Constituents and Elemental Profiling of Selected Medicinal Plants in South-West, Nigeria

Four New Benzoylamide Derivatives Isolated from the Seeds of Lepidium apetalum Willd. and Ameliorated LPS-Induced NRK52e Cells via Nrf2/Keap1 Pathway

Anxiolytic-like effect of Urena lobata (L.) in swiss albino mice

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