Lignanamides with potent antihyperlipidemic activities from the root bark of Lycium chinense

Chen, Hui; Li, Yujie; Sun, Yanjun; Gong, Jian; Du, Kun; Zhang, Yanli; Su, Cheng-Fu; Han, Qianqian; Zheng, Xiaoke; Feng, Weisheng

doi:10.1016/j.fitote.2017.09.004

Cited by 27 publications

(31 citation statements)

References 24 publications

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“…14,16,18,23 SCB, MAL, COL, and LCM have hypoglycemic effects and improve memory impairment by potentiating insulin sensitivity. 2,14,18,19,22 The present study showed that OJa1 and OJa2 attenuated memory impairment, depression, and vasomotor symptoms in menopausal women without stimulating the uterine proliferation. The results indicated that OJa1 and Oja2 improved the menopausal symptoms, not by direct activation of ER-α and they might alleviate them by activation of the downstream of ER signaling like insulin/IGF-1 signaling and/or stimulation of ER-β in the brain tissues.…”

Section: Discussionsupporting

confidence: 58%

“…(LCM; improvement of lipid profiles). 22 All the herbs in the ojayeonjonghwan remedies protect against oxidative stress and inflammation that suppress the release of lipopolysaccharide-induced cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-6, and IL-1β in peritoneal macrophages. 23 Ojayeonjonghwan remedies are traditionally known to be good for the reproductive functions of men and women.…”

Section: Introductionmentioning

confidence: 99%

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Ojayeonjonghwan, an oriental medicine composed of five seeds, protects against vasomotor and neurological disorders in estrogen-deficient rats

Ryuk

Hwang

et al. 2019

Exp Biol Med (Maywood)

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The different ojayeonjonghwan remedies all contain five fruit and seed water extracts, and they have been used for reproductive health in men and women. We hypothesized that the two OJa remedies would differently improve the early menopause-related vasomotor and neurological symptoms in estrogen-deficient animals. Ovariectomized (OVX) rats had either 0.5% dextrin (OVX-control), conjugated equine estrogen (150 μg/kg body weight; positive-control), 0.5% ojayeonjonghwan remedy-1 (OJa1), or 0.5% ojayeonjonghwan remedy-2(OJa2) in high-fat diet for 12 weeks. Normal-control rats (sham operation) were fed the same high-fat diet as OVX-control rats. Tail skin temperature, depressiveness, memory function, and body composition were determined. The mRNA expressions of hippocampal serotonin receptor (5HT)1A and 5HT2A and brain-derived neurotrophic factor(BDNF) were measured. OJa1 and OJa2 groups had lower tail skin temperatures than OVX-control. Bone mineral density (BMD) and lean body mass (LBM) measured by DEXA increased only in OJa2, and were similar to the positive- and normal-controls ( P < 0.05). In the forced swim test immobile time, an index of depressiveness was much lower in OJa1 and OJa2 than the control group. Memory as measured by passive avoidance, water maze, and Y maze tests was impaired in the OVX-control group, compared to the normal-control ( P < 0.05), but normalized in OJa1 comparable to the positive- and normal-control groups. The neurological impairments were associated with serum serotonin levels and 5HT2A mRNA expression in the midbrain, and decreased hippocampal BDNF mRNA and protein expressions in the OVX-control group compared to normal-controls ( P < 0.05). OJa1 increased serum serotonin levels and 5HT2A expression in the midbrain, and hippocampal BDNF expression to similar levels as normal-controls ( P < 0.05). In conclusion, OJa1 and OJa2 improved hot flashes and depression and maintained BMD and LBM. OJa2 prevented the impairment of memory function in OVX rats. OJa1 and OJa2 have the potential to be effective therapies for postmenopausal vasomotor and neurological symptoms. Impact statement Menopausal symptoms impair the quality of life of many women, and although conventional treatments are often effective, their use is limited by adverse effects. Ojayeonjonghwan, OJa, is a traditional Oriental medicine that is used for both male and female reproductive health and has a long history of safe use. We evaluated the effectiveness of two variations of OJa (OJa1 and OJa2) for treating menopausal symptoms in ovariectomized (OVX) rats. Both OJa preparations were effective for relieving indicators of hot flashes and depression, and for preventing loss of bone mineral density and lean body mass. Only OJa 2 prevented memory dysfunction. These results show that the traditional Oriental medicine, Ojayeonjonghwan, has the potential to relieve menopausal symptoms in women and should be further evaluated in human clinical trials as an alternative to convention therapies in women for whom conventional therapies are not indicated or found to be ineffective.

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Section: Discussionsupporting

confidence: 58%

Section: Introductionmentioning

confidence: 99%

Ojayeonjonghwan, an oriental medicine composed of five seeds, protects against vasomotor and neurological disorders in estrogen-deficient rats

Ryuk

Hwang

et al. 2019

Exp Biol Med (Maywood)

View full text Add to dashboard Cite

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“…It has also been reported to be the most widespread marker for susceptibility to atherosclerotic heart disease [3]. High levels of plasma lipids, mainly cholesterol, are a common feature of atherosclerosis, a condition in which arterial damage can lead to ischemic heart disease, myocardial infarction, and cerebrovascular coincidences [4]. Despite having several therapeutic measures, focus has now been given to establishing effective preventive strategies for detecting and controlling cardiovascular risk factors [5].…”

Section: Introductionmentioning

confidence: 99%

Antihyperlipidemic and Antioxidant Effects of Averrhoa Carambola Extract in High-Fat Diet-Fed Rats

et al. 2019

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The present study explored the antihyperlipidemic potential of a standardized methanolic extract of Averrhoa carambola (A. carambola) leaf (MEACL) in high-fat diet (HFD)-fed rats. The standardized MEACL was orally administered at different doses (250, 500, and 1000 mg/kg) to HFD-induced hyperlipidemic rats for five weeks. Serum lipid profile, body weight changes, body mass index (BMI), daily food intake, relative organ weight, and histology of the liver were evaluated. In addition, the effect of MEACL on HMG-CoA reductase and pancreatic lipase activities as well as hepatic and fecal lipids was demonstrated. MEACL supplementation reduced serum lipids in HFD-fed rats in a dose-dependent manner. Histopathological scores revealed that 1000 mg/kg MEACL restored the damage to liver tissue in hyperlipidemic rats. MEACL decreased the body mass index (BMI), atherogenic index, and hepatic cholesterol and triglycerides and increased fecal cholesterol and bile acids in HFD-fed rats. Also, MEACL ameliorated lipid peroxidation and improved antioxidant defenses in the liver of HFD-fed rats. Furthermore, HMG-CoA reductase and lipase were suppressed by MEACL. In conclusion, this study shows the potential effect of MEACL to ameliorate hyperlipidemia and oxidative stress in HFD-fed rats. It prevented hepatic lipid accumulation and exerted an inhibitory effect on HMG-CoA reductase and lipase.

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“…All the 1 H and 13 C-NMR data only accounted for half the number of atoms expected for its molecular formula (C 36 H 38 N 2 O 9 ), suggesting that 1 is a symmetrical dimer of two completely identical moieties (monomer units). The interpretation of the NMR data of 1 revealed that the monomer part was structurally similar to the known compound N - trans -feruloyltyramine [ 15 ], which co-occurs with 1 in the same extract. The 13 C-NMR chemical shifts and quaternary status of C-8/C-8′ (δ C 60.6), C-7/C-7′ (δ C 86.2) suggested that the two monomer units were connected via tetrahydrofuran (THF) unit [ 14 ].…”

Section: Results and Explanationmentioning

confidence: 99%

A New Lignanamide from the Root of Lycium yunnanense Kuang and Its Antioxidant Activity

et al. 2018

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A new lignanamide (1), lyciumamide K, together with four known analogues (2–5), was isolated from the root of Lycium yunnanense Kuang. Based on HR-ESI-MS, NMR spectral data and quantum chemistry ECD calculations, the structure of this new compound was confirmed, including its absolute configuration. Evaluation of the antioxidant activity of compounds 1–5 in the oxygen radical absorption capacity (ORAC) assay showed that they all exhibited significant antioxidant activities. Particularly, compound 1 showed the best activity with ORAC values (U/mol) of 7.90 ± 0.52. Thus, the new lignanamide may be a good source of bioavtive and protective compounds.

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Lignanamides with potent antihyperlipidemic activities from the root bark of Lycium chinense

Cited by 27 publications

References 24 publications

Ojayeonjonghwan, an oriental medicine composed of five seeds, protects against vasomotor and neurological disorders in estrogen-deficient rats

Ojayeonjonghwan, an oriental medicine composed of five seeds, protects against vasomotor and neurological disorders in estrogen-deficient rats

Antihyperlipidemic and Antioxidant Effects of Averrhoa Carambola Extract in High-Fat Diet-Fed Rats

A New Lignanamide from the Root of Lycium yunnanense Kuang and Its Antioxidant Activity

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