Lignans and Coumarins from the Roots of Anthriscus sylvestris and Their Increase of Caspase-3 Activity in HL-60 Cells

Jeong, Gil‐Saeng; Kwon, Ok‐Kyoung; Park, Bo-Young; Oh, Sei‐Ryang; Ahn, Ki Hoon; Chang, Min-Jung; Oh, Won Keun; Kim, Jin-Cheol; Min, Byung‐Sun; Kim, Youn‐Chul; Lee, Hyeong‐Kyu

doi:10.1248/bpb.30.1340

Cited by 45 publications

(44 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…(Umbelliferae) is a perennial herb that grows in Europe and in parts of North America, Africa, Asia and New Zealand (Jeong, 2007;Oktavia, 2011). The roots of A. sylvestris have been used as antitussive, antipyretic, analgesic, diuretic, and cough remedy in Chinese traditional medicine, and the young aerial part of this plant is used for food (Kozawa et al, 1978a;Wang et al, 1982;Yang et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Antitumor Constituents from Anthriscus Sylvestris (L.) Hoffm

Chen¹,

Jiang²,

Li³

et al. 2014

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Antitumor Constituents from Anthriscus Sylvestris (L.) Hoffm

Chen¹,

Jiang²,

Li³

et al. 2014

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

“…1. A. sylvestris is a perennial herb that grows in Europe, Caucasus, Siberia, Kamchatka, Kuriles, Sakhalin, China, Manchuria, and Korea [9]. The root of A. sylvestris has been used as therapy in coughing, asthma, laryngitis and anti-cancer.…”

Section: Resultsmentioning

confidence: 99%

“…The root of A. sylvestris has been used as therapy in coughing, asthma, laryngitis and anti-cancer. Also, it has been reported to exhibit anti-tumor activity, anti-platelet aggregation activity, anti-viral activity, anti-proliferation activity and broad insecticidal activity [9].…”

Section: Resultsmentioning

confidence: 99%

“…4). Final pure Instrumental data were compared to previously reported results [7,9,10]. In addition, physico-chemical properties were analyzed to be colorless oil; UV λmax (in methanol), 241, 293 nm.…”

Section: Resultsmentioning

confidence: 99%

“…Deoxypodophyllotoxin is a anti-tumor agent isolated from A. sylvestris which exhibits potent cytotoxity against a wide variety of tumor cell line [7,9]. To assess growth inhibition of deoxypodophyllotoxin on PC-3 cells, the cells were treated with a different concentration (0.8-800 nM) of deoxpodophyllotoxin for 0-48 hr.…”

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Screening and Purification of an Anti-Prostate Cancer Compound, Deoxypodophyllotoxin, from Anthriscus sylvestris Hoffm

Cho¹,

Yu²,

Kim³

et al. 2009

Journal of Life Science

View full text Add to dashboard Cite

The prostate cancer is the critical health problem, increasing of its related death in worldwide. Unfortunately present surgery and chemotherapeutic choices seem to be impossible in curing or controlling prostate cancer, because metastasis occasionally advances even after these potentially curative therapies. Therefore, there is immediate need to alternative chemoprevention and chemotherapeutic agents. Over one hundred species of dried medicinal herbs were tested for proliferation inhibitory effects on prostate cancer cell line, PC-3. One of them, Anthriscus sylvestris was selected because of potent anti-proliferation effect. The dried root of A. sylvestris was extracted with 100% methanol for 2-3 days and its extract was fractionated by using ethyl acetate. And ethyl acetate layer was subjected to column chromatographies on silica gel, reverse phase-18 (RP-18) and Sephadex LH-20, in turn. Finally, the pure compound was obtained by crystallization in methanol at 4 o C for overnight and identified as deoxypodophyllotoxin by NMR spectorscopic and physico-chemical analyses. In addition, it was confirmed that deoxypodophyllotoxin clearly inhibits the proliferation of PC-3 cells in a doseand time-dependent manner.

show abstract

Chemotypification of Astrantia major L. (Apiaceae): Essential‐Oil and Lignan Profiles of Fruits

Radulović

Mladenović

Ethorđević

2012

Chemistry & Biodiversity

View full text Add to dashboard Cite

The fruit essential oils of two populations of Astrantia major L. (Apiaceae, subfamily Saniculoideae) were analyzed in detail by GC and GC/MS analyses. Seventy-six constituents identified accounted for 92.7-94.0% of the oils. The two oils differed significantly: the wild-growing population from Serbia contained zingiberene (47.9%), β-bisabolene (9.7%), and β-sesquiphellandrene (7.9%), while the one from Poland (botanical gardens) was sesquiterpene-poor with the major contributors oleic acid (38.6%), nonacosane (15.4%), and linoleic acid (5.1%). Motivated by the unresolved taxonomical relations between the Saniculoideae and Apioideae subfamilies, we performed multivariate statistical analyses on the compositional data of these A. major samples, and additional 14 Saniculoideae and 31 Apioideae taxa. This allowed us to assess the chemotaxonomical usefulness of such chemical data in differentiating taxa from these two Apiaceae subfamilies and to corroborate the existence of at least two A. major chemotypes. Diethyl ether extracts of the two samples of A. major fruits yielded seven diaryltetrahydrofurofurano lignans. Except for eudesmin that has been found for the first time in a Saniculoideae taxon, all other lignans (magnolin, epimagnolins A and B, epieudesmin, yangambin, and epiyangambin) are new for the entire plant family Apiaceae. The lignan profiles also supported the existence of two separate A. major chemotypes.

show abstract

Lignans and Coumarins from the Roots of Anthriscus sylvestris and Their Increase of Caspase-3 Activity in HL-60 Cells

Cited by 45 publications

References 17 publications

Antitumor Constituents from Anthriscus Sylvestris (L.) Hoffm

Antitumor Constituents from Anthriscus Sylvestris (L.) Hoffm

Screening and Purification of an Anti-Prostate Cancer Compound, Deoxypodophyllotoxin, from Anthriscus sylvestris Hoffm

Chemotypification of Astrantia major L. (Apiaceae): Essential‐Oil and Lignan Profiles of Fruits

Contact Info

Product

Resources

About