Lignans and Neolignans with Antioxidant and Human Cancer Cell Proliferation Inhibitory Activities from <i>Cinnamomum bejolghota</i> Confirm Its Functional Food Property

Rao, L. Jagan Mohan; You, Yun-Xia; Su, Yu; Fan, Yue; Liu, Yu; He, Qian; Chen, Yi; Meng, Jie; Hu, Lin; Li, Yizhou; Xu, You-Kai; Lin, Bin; Zhang, Chuan‐Rui

doi:10.1021/acs.jafc.0c02885

Cited by 17 publications

(12 citation statements)

References 45 publications

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“…The first mentioned correlation showed no hit with a significance ≤ 0.05, which is in agreement with the additive/synergistic mode of action of compounds in such complex matrixes as plant crude extracts [45]. The antioxidant activity of flavonoids is well known for flavonoids isolated from Selaginella species [46], but the antioxidant activity of (neo)lignans [47] and selaginellins [33] has not been verified yet. However, it has to be mentioned that biochemical assays have their limitations-they omit such important parameters as compound availability, first-pass metabolism, ability to cross the membranes, etc.…”

Section: Discussionmentioning

confidence: 66%

Comparison of Chemical Composition and Biological Activities of Eight Selaginella Species

et al. 2020

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Selaginella P. Beauv. is a group of vascular plants in the family Selaginellaceae Willk., found worldwide and numbering more than 700 species, with some used as foods and medicines. The aim of this paper was to compare methanolic (MeOH) and dichloromethane (DCM) extracts of eight Selaginella species on the basis of their composition and biological activities. Six of these Selaginella species are underinvestigated. Using ultra-high performance liquid chromatography–high-resolution mass spectrometry (UHPLC–HRMS) analysis, we identified a total of 193 compounds among the tested Selaginella species, with flavonoids predominating. MeOH extracts recovered more constituents that were detected, including selaginellins, the occurrence of which is only typical for this plant genus. Of all the tested species, Selaginellaapoda contained the highest number of identified selaginellins. The majority of the compounds were identified in S. apoda, the fewest compounds in Selaginellacupressina. All the tested species demonstrated antioxidant activity using oxygen radical absorption capacity (ORAC) assay, which showed that MeOH extracts had higher antioxidant capacity, with the half maximal effective concentration (EC50) ranging from 12 ± 1 (Selaginellamyosuroides) to 124 ± 2 (Selaginellacupressina) mg/L. The antioxidant capacity was presumed to be correlated with the content of flavonoids, (neo)lignans, and selaginellins. Inhibition of acetylcholinesterase (AChE) was mostly discerned in DCM extracts and was only exhibited in S. myosuroides, S. cupressina, Selaginellabiformis, and S. apoda extracts with the half maximal inhibitory concentration (IC50) in the range of 19 ± 3 to 62 ± 1 mg/L. Substantial cytotoxicity against cancer cell lines was demonstrated by the MeOH extract of S. apoda, where the ratio of the IC50 HEK (human embryonic kidney) to IC50 HepG2 (hepatocellular carcinoma) was 7.9 ± 0.2. MeOH extracts inhibited the production of nitrate oxide and cytokines in a dose-dependent manner. Notably, S. biformis halved the production of NO, tumor necrosis factor (TNF)-α, and interleukin (IL)-6 at the following concentrations: 105 ± 9, 11 ± 1, and 10 ± 1 mg/L, respectively. Our data confirmed that extracts from Selaginella species exhibited cytotoxicity against cancer cell lines and AChE inhibition. The activity observed in S. apoda was the most promising and is worth further exploration.

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Section: Discussionmentioning

confidence: 66%

Comparison of Chemical Composition and Biological Activities of Eight Selaginella Species

et al. 2020

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“…Compounds 1 – 3 were evaluated for antimicrobial activity [30,31] against six bacterial strains, Bacillus subtilis , Bacterium paratyphosum B, Methicillin‐resistant Staphylococcus aureus , Micrococcus lysodeikticus , Pseudomonas aeruginosa and Salmonella typhimurium , and six fungal strains, Alternaria alternate , Gibberella saubinetii , Phytophthora parasitica , Rhizoctonia solani , Sclerotinia sclerotiorum and Verticillium dahliae Kleb, and for cytotoxicity [32] against a panel of five human cancer cell lines, A549 (lung), HCT‐116 (colon), MDA‐MB‐231 (breast), PC‐3 (prostate adenocarcinoma) and SH‐SY5Y (neuroblastoma). Unfortunately, the results showed all of them were not active with MIC values of >100 μM for antimicrobial activity and IC 50 values of >50 μM for cytotoxicity.…”

Section: Resultsmentioning

confidence: 99%

“…All the isolates and positive control (adriamycin) were evaluated for cytotoxicity against A549 (lung), HCT‐116 (colon), MDA‐MB‐231 (breast), PC‐3 (prostate adenocarcinoma) and SH‐SY5Y (neuroblastoma) human cancer cell lines as per published method [32] . The detailed information could be found in Supporting Information .…”

Section: Methodsmentioning

confidence: 99%

Neolignans and Sesquiterpenoid from Piper yunnanense

Chen

You

Rao

et al. 2021

Chemistry & Biodiversity

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Two biphenyl‐type neolignans with a rare dibenzofuran skeleton, including a new one piyunneolignan A (1) and a known one piperneolignan D (2), together with a new sesquiterpenoid piyunin A (3), were isolated from the leaves and twigs of Piper yunnanense. Their structures were established on the basis of comprehensive spectroscopic data analysis and electronic circular dichroism (ECD) calculation. Piyunneolignan A (1) featured a rare C‐2−C‐2′/C‐3−O−C‐3′ linkage. Compounds 1–3 were evaluated for their antimicrobial and cytotoxic activities against a panel of bacteria, fungi, and human cancer cell lines, respectively.

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“…Compound 1 and adriamycin (positive control) were evaluated for cytotoxicity on human cancer cell lines (A549, HCT‐116, MDA‐MB‐231 and PC‐3) using a method previously reported [29] . The details were provided in Supporting Information .…”

Section: Methodsmentioning

confidence: 99%

“…[27,28] Cytotoxicity of compound 1 was studied on A549 (lung), HCT-116 (colon), MDA-MB-231 (breast), and PC-3 (prostate adenocarcinoma) cancer cell lines. [29] Unfortunately, the results showed it was not active (IC 50 > 10 μM).…”

Section: Introductionmentioning

confidence: 99%

Two Novel Flavonoids and Cytotoxicity Evaluation from Cryptocarya yunnanensis

Song

et al. 2022

Chemistry & Biodiversity

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Two new flavonoids, cryunchalcone (1) and cryptoyunnanone I (2), were isolated from the leaves and twigs of Cryptocarya yunnanensis. Their structures were elucidated by the detailed spectroscopic data analysis and electronic circular dichroism (ECD) calculations. Cryunchalcone (1) is a biflavonoid constructed by a dihydrochalcone coupled with a chalcone through an unprecedented C‐2′′−C‐6 linkage. Cryptoyunnanone I (2) is a unique complex flavanone bearing a phenylpropanoid moiety.

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Lignans and Neolignans with Antioxidant and Human Cancer Cell Proliferation Inhibitory Activities from Cinnamomum bejolghota Confirm Its Functional Food Property

Cited by 17 publications

References 45 publications

Comparison of Chemical Composition and Biological Activities of Eight Selaginella Species

Comparison of Chemical Composition and Biological Activities of Eight Selaginella Species

Neolignans and Sesquiterpenoid from Piper yunnanense

Two Novel Flavonoids and Cytotoxicity Evaluation from Cryptocarya yunnanensis

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