Lignans and other compounds from the mixe indian medicinal plant Hyptis verticillata

Selection methodology with scoring system: Application to Mexican plants producing podophyllotoxin related lignans

“…Finally, the results confirmed the importance of the chemotaxonomical criterion for selecting plants, taking into account the following considerations: (1) the presence of podophyllotoxin in Hyptis suaveolens is not surprising, since another Mexican species Hyptis verticillata accumulates podophyllotoxin and other cyclolignans (Kuhnt et al, 1994). (2) Neither is the presence of a compound which may be very closely related to 6-methoxypodophyllotoxin in Linum scabrellum surprising, as according to Konuklugil et al (2007), the lignans produced by the Linum species depend on which section of the genus they pertain to.…”

Isolation and identification of an endophytic strain of Fusarium oxysporum producing podophyllotoxin from Juniperus recurva

“…Podophyllotoxin, a bioactive lignan is a valuable natural product as a precursor to three anticancer drugs etoposide, tenopside and etopophose phosphate (Schacter 1996). Podophyllotoxin has also been reported in other plant genera, such as Linum, Juniperus, Hyptis, Teuricum, Nepata, Dysosma, Jeffersonia, Thymus and Thuja, (Kupchan et al 1965;San Feliciano et al 1989a, b;Broomhead and Dewick 1990a, b;Yu et al 1991;Kuhnt et al 1994;Konuklugil 1996a, b;Muranaka et al 1998;Bedir et al 2001). Literature survey on podophyllotoxin revealed that the molecule occupies an important position among the plant based anti-cancer drugs, (Imbert 1998;Utsugi et al 1996;Subrahmanyam et al 1998;Schacter 1996;Farkya et al 2004;Germaine et al 2004;Kupchan et al 1965;San Feliciano et al 1989a, b;Broomhead and Dewick 1990a, b;Yu et al 1991;Kuhnt et al 1994;Konuklugil 1996a, b;Muranaka et al 1998;Bedir et al 2001).…”

“…Podophyllotoxin has also been reported in other plant genera, such as Linum, Juniperus, Hyptis, Teuricum, Nepata, Dysosma, Jeffersonia, Thymus and Thuja, (Kupchan et al 1965;San Feliciano et al 1989a, b;Broomhead and Dewick 1990a, b;Yu et al 1991;Kuhnt et al 1994;Konuklugil 1996a, b;Muranaka et al 1998;Bedir et al 2001). Literature survey on podophyllotoxin revealed that the molecule occupies an important position among the plant based anti-cancer drugs, (Imbert 1998;Utsugi et al 1996;Subrahmanyam et al 1998;Schacter 1996;Farkya et al 2004;Germaine et al 2004;Kupchan et al 1965;San Feliciano et al 1989a, b;Broomhead and Dewick 1990a, b;Yu et al 1991;Kuhnt et al 1994;Konuklugil 1996a, b;Muranaka et al 1998;Bedir et al 2001). There are several constraints in meeting the demand of bioactive lignan because (i) its chemical synthesis is not commercially feasible due to the presence of four chiral centres along with a c lactone and high degree of oxygenation (Dayamanti and Lawn 1998;Berkovitz et al 2000) and (ii) difficulties in approaching towards good yield through biotechnological aspects (Berlin et al 1988;Empt et al 2001;Giri and Narasu 2000;Peterson and Alferman 2001).…”

Molecular Approaches to Screen Bioactive Compounds from Endophytic Fungi

“…The presence of podophyllotoxin and its various precursors have been reported from all the species of Podophyllum , a herbaceous perennial alpine rosette belonging to family berberidaceae (Haijun et al, 2004). Some of the other plant species which produce podophyllotoxin include Linum flavum (Broomhead and Dewick, 1990), Juniperus verginiana (Kupchan et al, 1965), Hyptis verticillata (Kuhnt et al, 1994). Due to over extraction and slow growing nature, Podophyllum plants have been listed among the endangered plant species (Chaurasia et al, 2012).…”