Lignans from the Twigs of <i>Euonymus</i> <i>alatus</i> (<scp>Thunb</scp>.) <scp>Siebold</scp> and Their Biological Evaluation

Lee, Seulah; Moon, Eunjung; Choi, Sang Un; Kim, Ki‐Hyun

doi:10.1002/cbdv.201600083

Cited by 21 publications

(7 citation statements)

References 29 publications

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“…(+)-Medioresinol from the anti-inflammatory, analgesic, and diuretic herbal plant Sambucus williamsii , imposed on C. albicans, could induce generation of ROS and cell cycle arrest and finally apoptosis [ 47 ]. Although (+)-medioresinol could inhibit in vitro the proliferation of mammalian cells such as A549, SK-MEL-2, SK-OV-3, and HCT-15 cells at high concentrations, the IC 50 values for these cell lines were much higher than the MIC value against C. albicans cells [ 47 , 63 ]. In a cohort study in Sweden, (+)-medioresinol in food did not clearly reduce the risk of esophageal and gastric cancers, but at least this compound in diet did not show bad effects [ 64 , 65 ].…”

Section: Compounds Targeting Mitochondriamentioning

confidence: 99%

Antifungal Compounds againstCandidaInfections from Traditional Chinese Medicine

Liu

Zhang

et al. 2017

BioMed Research International

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Infections caused by Candida albicans, often refractory and with high morbidity and mortality, cause a heavy burden on the public health while the current antifungal drugs are limited and are associated with toxicity and resistance. Many plant-derived molecules including compounds isolated from traditional Chinese medicine (TCM) are reported to have antifungal activity through different targets such as cell membrane, cell wall, mitochondria, and virulence factors. Here, we review the recent progress in the anti-Candida compounds from TCM, as well as their antifungal mechanisms. Considering the diverse targets and structures, compounds from TCM might be a potential library for antifungal drug development.

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Section: Compounds Targeting Mitochondriamentioning

confidence: 99%

Antifungal Compounds againstCandidaInfections from Traditional Chinese Medicine

Liu

Zhang

et al. 2017

BioMed Research International

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“…The cytotoxic activities of all the isolates 1 – 9 were evaluated by determining their inhibitory effects on human tumor cell growth in A549 (non‐small cell lung carcinoma), SK‐OV‐3 (ovary malignant ascites), SK‐MEL‐2 (skin melanoma), and Bt549 (invasive human breast carcinoma) cells using the SRB bioassay . The results ( Table ) demonstrated that all of the compounds showed significant cytotoxicity against the four tumor cell lines tested, except compound 1 was inactive ( IC 50 > 30.0 μ m ) against the SK‐OV‐3 and Bt549 cell lines.…”

Section: Resultsmentioning

confidence: 99%

Cytotoxic Triterpenoids from the Barks of Betula platyphylla var. japonica

Eom

Kang

Choi

et al. 2017

Chemistry & Biodiversity

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Phytochemical investigation on the barks of Betula platyphylla var. japonica (Betulaceae) was carried out, resulting in the isolation and identification of three new triterpenoids, 27-O-cis-caffeoylcylicodiscic acid (1), 27-O-cis-feruloylcylicodiscic acid (2), and 27-O-cis-caffeoylmyricerol (3), along with six known triterpenoids, obtusilinin (4), winchic acid (5), 27-O-trans-caffeoylcylicodiscic acid (6), uncarinic acid E (7), myriceric acid B (8), and 3-O-trans-caffeoyloleanolic acid (9). The structures of the new compounds were elucidated by extensive spectroscopic methods, including 1D- and 2D-NMR, and HR-ESI-MS. All of the isolated compounds were evaluated for cytotoxicity against four human tumor cell lines (A549, SK-OV-3, SK-MEL-2, and Bt549). Compounds 2, 6, 8, and 9 exhibited potent cytotoxicity against all of the tumor cells tested (IC < 10.0 μm), while compounds 3, 4, 5, and 7 showed moderate cytotoxicity against all of the tumor cells tested (IC < 20.0 μm).

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“…), 59 in the form of sesquiterpenes, including sesquiterpene alkaloids, triterpenes, flavonoids, and phenolic compounds, such as β-sitosterol, aromadendrin, and alatamine. 24,60 Many compounds have been isolated from Ligusticum chuanxiong Hort, 61 including ligustilide, tetramethyl pyrazine (TMP), and ferulic acid. 25 Previous animal experiments conducted by our research group have shown that SMYZD exerts a significant effect on the treatment of dementia.…”

Section: Introductionmentioning

confidence: 99%

ShenmaYizhi Decoction Improves the Mitochondrial Structure in the Brain and Ameliorates Cognitive Impairment in VCI Rats via the AMPK/UCP2 Signaling Pathway

Sun¹,

Liu²,

Liu³

et al. 2021

NDT

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Background ShenmaYizhi decoction (SMYZD) is an effective prescription of traditional Chinese medicine used to treat vascular dementia (VD). Modern research methods have identified its active ingredients clearly as gastrodin, ferulic acid, ginsenosides, and β-sitosterol. Chronic cerebral hypoperfusion is a driving factor or risk factor for VD, which leads to the disturbance of mitochondrial structure and function. Purpose To observe whether SMYZD improves cognitive impairment by improving mitochondrial structure and function. Methods Forty adult rats with vascular cognitive impairment (VCI) caused by the bilateral ligation of common carotid arteries were divided into four groups randomly, including the model group, donepezil group, and low-dose and high-dose SMYZD groups, with 10 rats in each group. Additionally, a sham group was established with 10 rats as the control group. The treatment groups were administered donepezil and two different dosages of SMYZD. The donepezil group was administered 0.45 mg/kg/d donepezil, and the SMYZ-L group was administered 2.97 g/kg/d SMYZ, which were equivalent to the clinical dosage. The SMYZ-H group was administered 11.88 g/kg/d SMYZ, which is 4 times higher than the clinically equivalent dosage. A sham-operated group was used as the control group and administered an equal volume of distilled water. The rats were treated by gavage for 8 consecutive weeks. Morris water maze (MWM) test was performed to evaluate the learning and memory ability. The mitochondria of brain tissue were extracted from brain for further test. Mitochondrial morphology and the signal path of AMPK/PPARα/PGC-1α/UCP2 in mitochondria were detected. Results With the SMYZD intervention, behavioral performance of rats and pathological changes of mitochondria of brain tissue were signiﬁcantly improved. In the serum, SOD, GSH-Px, and GSH activities were increased, and the MDA content was decreased. Moreover, the AMPK, PPARα, PGC-1α, UCP2, and ATP5A mRNA and protein expression levels were also reversed by SMYZD. Conclusion SMYZD may provide a potential therapeutic strategy via activating the AMPK/PPARα/PGC-1α/UCP2 signal pathway to improve mitochondrial structure and energy metabolism thereby alleviate vascular cognitive impairment.

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Lignans from the Twigs of Euonymus alatus (Thunb.) Siebold and Their Biological Evaluation

Cited by 21 publications

References 29 publications

Antifungal Compounds againstCandidaInfections from Traditional Chinese Medicine

Antifungal Compounds againstCandidaInfections from Traditional Chinese Medicine

Cytotoxic Triterpenoids from the Barks of Betula platyphylla var. japonica

ShenmaYizhi Decoction Improves the Mitochondrial Structure in the Brain and Ameliorates Cognitive Impairment in VCI Rats via the AMPK/UCP2 Signaling Pathway

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