Lignans of sesame: Purification methods, biological activities and biosynthesis – A review

Dar, Aejaz Ahmad; Arumugam, N.

doi:10.1016/j.bioorg.2013.06.009

Cited by 163 publications

(95 citation statements)

References 111 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Lignans represent an abundant and widespread group of compounds demonstrating a wide range of biological activities, such as anticancer (review by Landete 2012), antimicrobial, anti-inflammatory (Küpeli et al 2003;During et al 2012), hypoglycemic (Banskota et al 2006; reviews by: Erdemoglu et al 2004;Saleem et al 2005;Topcu and Demirkiran 2007;Dar and Arumugam 2013), antioxidant (Masuda et al 2010), cardioprotective (Zanwar et al 2011) and anti-osteoporotic (Yin et al 2006). Lignan food ingredients such as secoisolariciresinol, matairesinol, lariciresinol and pinoresinol are conversed by intestinal bacteria to enterolignans: enterodiol and enterolactone and were reported to reduce the risk of some cancers and cardiovascular diseases (Milder et al 2007;Ghisalberti 1997;Landete 2012) and exhibited estrogen activity (Cassidy et al 2000;Aehle et al 2011).…”

Section: Introductionmentioning

confidence: 99%

Lignan accumulation in two-phase cultures of Taxus x media hairy roots

Sykłowska-Baranek

Łysik

Jeziorek

et al. 2018

Plant Cell Tiss Organ Cult

View full text Add to dashboard Cite

The biosynthetic potential for six lignans accumulation in two lines of Taxus x media hairy roots was investigated. The cultures of KT and ATMA hairy root lines were supplemented with precursors: coniferyl alcohol (CA 1, 10 or 100 µM) and/or l-phenylalanine (100 µM PHEN) and/or methyl jasmonate (100 µM MeJa). Moreover the two-phase in vitro cultures supported with perfluorodecalin (PFD) as a gas carrier and in situ extrahent were used. The hairy root lines differed in lignan production profiles. In the control untreated cultures KT roots did not accumulate secoisolariciresinol and lariciresinol while ATMA roots did not accumulate matairesinol. In ATMA roots the treatment with CA (1 or 10 µM) resulted in the production of lariciresinol and secoisolariciresinol whereas solely lariciresinol was present after 100 µM CA application. Elicitation with 1 µM CA and MeJa yielded with hydroxymatairesinol aglyca and lariciresinol glucosides with their highest content 37.88 and 3.19 µg/g DW, respectively. The stimulatory effect of simultaneous treatment with 1 µM CA, PHEN and MeJa on lignan production was observed when the cultures were supplemented with PFD-aerated or degassed. In ATMA root cultures these applied conditions were the most favourable for matairesinol content which amounted to 199.86 and 160.25 µg/g DW in PFD-aerated and PFD-degassed supported cultures, respectively. In KT root cultures solely, hydroxymatairesinol and coniferin/CA content was enhanced with their highest yield 59.29 and 134.60 µg/g DW in PFD-aerated and PFD-degassed cultures, respectively.

show abstract

Section: Introductionmentioning

confidence: 99%

Lignan accumulation in two-phase cultures of Taxus x media hairy roots

Sykłowska-Baranek

Łysik

Jeziorek

et al. 2018

Plant Cell Tiss Organ Cult

View full text Add to dashboard Cite

show abstract

“…In China and India, people used sesame oil to ameliorate burns, and as a lubricant in massage [25]. In addition, sesame oil has an antimicrobial effect against Staphylococcus, and it suppresses fungal infections [20].…”

Section: Discussionmentioning

confidence: 99%

“…Recent phytochemical studies found that Sesamun indicum contained several lignans, including sesamol, sesamin, sesamolin, and sesaminol [20]. Sesamin was found to suppress chemokine production via the MAPK, PPAR-a, and NF-jB pathways in LPS-activated human monocytes [26].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Sesamol suppresses the inflammatory response by inhibiting NF-κB/MAPK activation and upregulating AMP kinase signaling in RAW 264.7 macrophages

Liou

et al. 2015

Inflamm. Res.

View full text Add to dashboard Cite

show abstract

“…Many studies on the chemical constituents and biological activities have focused on the seeds of S. indicum (Kiso 2004;Chakraborthy et al 2008;Dar & Arumugam 2013). However, the leaf of this plant has not been well investigated except for the gastroprotective and antimicrobial effects of the leaf extracts (Ribeiro et al 1998;Bankole et al 2007;Okwuosa et al 2011).…”

Section: Introductionmentioning

confidence: 96%

New flavonoid and pentacyclic triterpene fromSesamum indicumleaves

Dat

Dang

2015

Natural Product Research

View full text Add to dashboard Cite

Two new and one known compounds were isolated from the methanol extract of Sesamum indicum leaves. By means of spectroscopic methods, their structures were elucidated and identified to be 3-epibartogenic acid (1), kaempferol 3-O-[2-O-(trans-p-coumaroyl)-3-O-α-L-rhamnopyranosyl]-β-D-glucopyranoside (2) and epigallocatechin (3). Compound 1 and 3 strongly inhibited α-amylase with the IC50 values of 146.7 and 303.9 μM, respectively, in comparison with acarbose (IC50 124.0 μM).

show abstract

Lignans of sesame: Purification methods, biological activities and biosynthesis – A review

Cited by 163 publications

References 111 publications

Lignan accumulation in two-phase cultures of Taxus x media hairy roots

Lignan accumulation in two-phase cultures of Taxus x media hairy roots

Sesamol suppresses the inflammatory response by inhibiting NF-κB/MAPK activation and upregulating AMP kinase signaling in RAW 264.7 macrophages

New flavonoid and pentacyclic triterpene fromSesamum indicumleaves

Contact Info

Product

Resources

About