Ligneous Conjunctivitis with Oral Mucous Membrane Involvement and Decreased Plasminogen Level

Abstract

Ligneous conjunctivitis (MIM 217090) is a rare autosomal recessive hereditary disorder. We report a case with both ligneous conjunctivitis and ligneous periodontitis in association with plasminogen type I deficiency. Diagnosis was based on the clinical and histological findings and most importantly, decreased serum level of plasminogen type I.

Orthomolecular nutritional therapy for plasminogen deficiency: report of a case that showed positive results

“…Besides the ocular region, other mucous membranes may be involved, such as oral, nasopharyngeal, gum, trachea and vagina . Several cases of conjunctivitis ligneous and/or ligneous periodontitis were found in association with plasminogen deficiency type I .…”

Immunohistochemical analysis of the gingiva with periodontitis of type I plasminogen deficiency compared to gingiva with gingivitis and periodontitis and healthy gingiva

“…To date there have been many case reports reporting ligneous gingival lesions (El Darouti et al, 2009;Fine, Bauer, Al Mohaya, & Woo, 2009;Galeotti et al, 2014;Gokbuget et al, 1997;Gunhan et al, 1994Gunhan et al, , 1999Gunhan et al, 2012;Kurtulus et al, 2007;Scully et al, 2001;Silva, Bariani, Mendonca, & Batista, 2006;Suresh et al, 2003;Toker, Toker, Goze, Turgut, & Yilmaz, 2007), however, as far as we know, the possible role that plg may play in the maintenance of periodontal health has been first studied by Sulniute et al (2011) in mice. The authors were the first to show that the development of periodontitis in mice resembles that in humans and is characterized by the formation of necrotic tissue, the inflow of neutrophils, detachment of gingival tissue from the teeth, followed by severe alveolar bone resorption (Sulniute et al, 2011).…”

Genetics of ligneous membranitis in a family of Scottish terriers

“…This is a rare chronic inflammatory disease of the mucous membranes associated with plasminogen deficiency. The condition is well characterised in humans and is inherited in an autosomal recessive pattern (Schuster and others , Tefs and others , El‐Darouti and others , Gunhan and others ).…”